Recent Advances in Continuous Glucose Monitoring Sensors

Dear Colleagues,

In the last 20 years, we have experienced a revolution of glucose monitoring with the introduction of continuous glucose monitoring (CGM) sensors that can measure interstitial glucose concentration almost continuously for several days or weeks. CGM sensors can really be a game changer in the therapy of diabetes (especially type 1 diabetes), because the rich information they provide can be used to improve both patient and clinician decision-making with positive effects on glycemic control.

Most CGM devices currently on the market are based on minimally invasive electrochemical sensors. Implantable fluorescence sensors have also recently been developed and brought into the market. Other technologies have been investigated for noninvasive monitoring of glucose concentration in various biological fluids (e.g., interstitial fluid, tears, and saliva).

Although the first CGM sensors suffered from poor accuracy and required frequent calibration with capillary glucose measurements, great improvements were recently achieved for both sensing technologies and processing algorithms, with resulting improvements in sensor accuracy. Nevertheless, the accuracy of CGM sensors can still be problematic in some situations, such as immediately after sensor insertion, in proximity of the sensor end-of-life, and during rapid glucose changes. Moreover, the estimation of glucose trends and the generation of predictive alerts remains challenging because of the presence of noise on the CGM trace.

In this Special Issue, we seek original papers and review papers on the recent advances in CGM sensors, including:

• New CGM technologies (e.g., new sensing technologies);
• New algorithms for improving the analytical performance of CGM sensors (e.g., calibration and filtering algorithms);
• New algorithms to enhance the output of CGM devices (e.g., new algorithms for trend estimation and alert generation).

Dr. Martina Vettoretti
Dr. Andrea Facchinetti
Prof. Dr. Giovanni Sparacino
Guest Editors

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