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Bio- and Chemical Sensors for Biomedical Applications

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 18182

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Special Issue Editor

Dr. Piyush Sindhu Sharma

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Guest Editor

Institute of Physical Chemistry Polish Academy of Sciences, Kasprzaka Str. 44/52, 01-224 Warsaw, Poland
Interests: synthetic receptors; molecularly imprinted polymer; chemosensor; polymer modified electrodes; electrocatalysis; conducting polymers; stimuli-responsive polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

The concentration levels of biomolecules in body fluids provide an early indication of certain diseases. Biosensors and chemical sensors are employed to measure changes in the levels of biomolecules in such samples for early diagnosis purposes. The increase of healthcare costs demands alternative techniques for the development of low-cost diagnostic tools.

Progress in the field of biosensors and chemical sensors has greatly improved the analytical performance of these devices. The number of publications describing the integration of different types of recognition units with different transducers is growing rapidly. Moreover, fundamental work focused on understanding the interactions between bio-receptors (host) and biomolecules (guest) is considered as high-priority research in the sensing field. Such research will help design and fabricate artificial synthetic recognition units mimicking biological systems.

For this Special Issue, we welcome original research papers describing the development and fabrication of chemo- and biosensors for the determination of biomolecules levels in body fluids. This Special Issue will include research articles describing sensors developed as point-of-care diagnostic tools for biomedical applications. Manuscripts describing possible solutions for the existing challenges regarding diagnostic devices will be given priority. Moreover, we plan to publish critical review articles describing the progress in the above-mentioned fields.

Dr. Piyush Sindhu Sharma
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Synthetic receptors for sensing
Point-of-care diagnostics based on synthetic and natural receptors
Chemical sensors for biomedical application
Biosensors for biomedical application
Modified electrodes for sensing

Published Papers (4 papers)

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Research

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12 pages, 4350 KiB

Open AccessArticle

DNAzyme-Based Target-Triggered Rolling-Circle Amplification for High Sensitivity Detection of microRNAs

by Chen Liu, Jialun Han, Lujian Zhou, Jingjing Zhang and Jie Du

Sensors 2020, 20(7), 2017; https://doi.org/10.3390/s20072017 - 03 Apr 2020

Cited by 11 | Viewed by 3452

Abstract

MicroRNAs regulate and control the growth and development of cells and can play the role of oncogenes and tumor suppressor genes, which are involved in the occurrence and development of cancers. In this study, DNA fragments obtained by target-induced rolling-circle amplification were constructed to complement with self-cleaving deoxyribozyme (DNAzyme) and release fluorescence biomolecules. This sensing approach can affect multiple signal amplification permitting fluorescence detection of microRNAs at the pmol L⁻¹ level hence affording a simple, highly sensitive, and selective low cost detection platform. Full article

(This article belongs to the Special Issue Bio- and Chemical Sensors for Biomedical Applications)

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Graphical abstract

12 pages, 2766 KiB

Open AccessArticle

Optical Polarimetric Detection for Dental Hard Tissue Diseases Characterization

by Tien-Yu Hsiao, Shyh-Yuan Lee and Chia-Wei Sun

Sensors 2019, 19(22), 4971; https://doi.org/10.3390/s19224971 - 14 Nov 2019

Cited by 6 | Viewed by 2616

Abstract

Dental enamel constitutes the outer layer of a crown of teeth and grows nearly parallel. This unique nanostructure makes enamel possess birefringence properties. Currently, there is still no appropriate clinical solution to examine dental hard tissue diseases. Therefore, we developed an optical polarization imaging system for diagnosing dental calculus, caries, and cracked tooth syndrome. By obtaining Stokes signals reflected from samples, Mueller images were constructed and analyzed using Lu-Chipman decomposition. The results showed that diattenuation and linear retardance images can distinguish abnormal tissues. Our result also aligns with previous studies assessed by other methods. Polarimetric imaging is promising for real-time diagnosing. Full article

(This article belongs to the Special Issue Bio- and Chemical Sensors for Biomedical Applications)

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25 pages, 7469 KiB

Open AccessArticle

Adaptable Xerogel-Layered Amperometric Biosensor Platforms on Wire Electrodes for Clinically Relevant Measurements

by Lillian B. Hughes, Najwa Labban, Grace E. Conway, Julie A. Pollock and Michael C. Leopold

Sensors 2019, 19(11), 2584; https://doi.org/10.3390/s19112584 - 06 Jun 2019

Cited by 7 | Viewed by 3545

Abstract

Biosensing strategies that employ readily adaptable materials for different analytes, can be miniaturized into needle electrode form, and function in bodily fluids represent a significant step toward the development of clinically relevant in vitro and in vivo sensors. In this work, a general scheme for 1st generation amperometric biosensors involving layer-by-layer electrode modification with enzyme-doped xerogels, electrochemically-deposited polymer, and polyurethane semi-permeable membranes is shown to achieve these goals. With minor modifications to these materials, sensors representing potential point-of-care medical tools are demonstrated to be sensitive and selective for a number of conditions. The potential for bedside measurements or continuous monitoring of analytes may offer faster and more accurate clinical diagnoses for diseases such as diabetes (glucose), preeclampsia (uric acid), galactosemia (galactose), xanthinuria (xanthine), and sepsis (lactate). For the specific diagnostic application, the sensing schemes have been miniaturized to wire electrodes and/or demonstrated as functional in synthetic urine or blood serum. Signal enhancement through the incorporation of platinum nanoparticle film in the scheme offers additional design control within the sensing scheme. The presented sensing strategy has the potential to be applied to any disease that has a related biomolecule and corresponding oxidase enzyme and represents rare, adaptable, sensing capabilities. Full article

(This article belongs to the Special Issue Bio- and Chemical Sensors for Biomedical Applications)

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Review

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17 pages, 5115 KiB

Open AccessFeature PaperReview

Surface Display Technology for Biosensor Applications: A Review

by Min Park

Sensors 2020, 20(10), 2775; https://doi.org/10.3390/s20102775 - 13 May 2020

Cited by 49 | Viewed by 8026

Abstract

Surface display is a recombinant technology that expresses target proteins on cell membranes and can be applied to almost all types of biological entities from viruses to mammalian cells. This technique has been used for various biotechnical and biomedical applications such as drug screening, biocatalysts, library screening, quantitative assays, and biosensors. In this review, the use of surface display technology in biosensor applications is discussed. In detail, phage display, bacterial surface display of Gram-negative and Gram-positive bacteria, and eukaryotic yeast cell surface display systems are presented. The review describes the advantages of surface display systems for biosensor applications and summarizes the applications of surface displays to biosensors. Full article

(This article belongs to the Special Issue Bio- and Chemical Sensors for Biomedical Applications)

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