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Novel Biosensors Based on Nanomaterials

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 530

Special Issue Editors


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Guest Editor
Polymers and Complex Fluids Group, National Institute of Technology, 100 Bureau Dr., Gaithersburg, MD 20899, USA
Interests: optical sensors; carbon nanomaterials; molecular detection; medical nanotechnology

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Guest Editor
Department of Chemical Engineering, Massachusetts Institute of Technology, 25 Ames St, Cambridge, MA, 02139, USA
Interests: 2D polyaramids; nanotechnology

Special Issue Information

Dear Colleagues,

Nanomaterials have revolutionized the field of biosensing, offering unparalleled sensitivity, selectivity, and functionality. This Special Issue, entitled Novel Biosensors Based on Nanomaterials, explores the development and application of biosensors that leverage these advanced materials to detect and quantify biological or chemical substances across diverse fields. These innovative biosensors integrate nanomaterials such as carbon-based materials (e.g., graphene, nanotubes), metal nanoparticles, quantum dots, and polymer nanocomposites, which exhibit unique electronic, optical, and mechanical properties.

Nanomaterials can be employed in domains such as healthcare diagnostics, environmental monitoring, food safety assurance, and industrial process control. While nanomaterials have significantly enhanced the performance of biosensors, challenges such as scalability, stability, and reproducibility remain. Advances in nanotechnology, materials science, and data integration via the application of IoT, AI, and ML are leading to innovations that address these limitations, paving the way for next-generation biosensors with enhanced robustness and practical applicability.

Dr. Xiaojia Jin
Dr. Zitang Wei
Guest Editors

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Keywords

  • nanomaterials
  • biosensors
  • nanotechnology
  • point-of-care diagnostics
  • molecular recognition
  • electrochemical sensors
  • optical sensors

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Published Papers (1 paper)

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Research

18 pages, 2959 KiB  
Article
Luminous Upconverted Nanoparticles as High-Sensitivity Optical Probes for Visualizing Nano- and Microplastics in Caenorhabditis elegans
by Bushra Maryam, Yi Wang, Xiaoran Li, Muhammad Asim, Hamna Qayyum, Pingping Zhang and Xianhua Liu
Sensors 2025, 25(11), 3306; https://doi.org/10.3390/s25113306 - 24 May 2025
Viewed by 367
Abstract
With the increasing prevalence of plastic pollution, understanding its impact on soil nematodes is crucial for environmental sustainability and food security. Traditional fluorescence-based probes have the limitations of high background noise and interference from autofluorescence. In this study, the luminous upconverted NaYF4:Yb3+ [...] Read more.
With the increasing prevalence of plastic pollution, understanding its impact on soil nematodes is crucial for environmental sustainability and food security. Traditional fluorescence-based probes have the limitations of high background noise and interference from autofluorescence. In this study, the luminous upconverted NaYF4:Yb3+/Er3+ nanoparticles acted as high-sensitivity probes for real-time visualization of ingestion and biodistribution of polystyrene microplastics (PS-MPs) and nanoplastics (PS-NPs) in Caenorhabditis elegans. The novel probes enabled efficient near-infrared-to-visible light conversion. This approach improved the precision of nano- and microplastic detection in biological tissues. Microscopic imaging revealed that the probes effectively distinguished size-dependent plastic distribution patterns, with microplastics remaining in the digestive tract, whereas nanoparticles penetrated intestinal walls and entered systemic circulation. Quantitative fluorescence analysis confirmed that PS-NPs exhibited higher bioavailability and deeper tissue penetration, providing crucial insights into plastic behavior at the organismal level. The different toxicities of PS-NPs and PS-MPs were further confirmed by measurement of the locomotor impairments and the physiological disruptions. These findings emphasize the broader applications of upconverted nanoparticles as advanced bio-imaging probes, offering a sensitive and non-invasive tool for tracking pollutant interactions in environmental and biological systems. Full article
(This article belongs to the Special Issue Novel Biosensors Based on Nanomaterials)
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