CFD for Design and Optimization of Biopharmaceutical Processes

Dear Colleagues,

Advanced therapeutics, such as monoclonal antibodies (mAbs), mRNA, cell, and genetic therapies, are amongst the most powerful tools for elevating global health. From rare cancers to viral infections, such as the recent COVID-19 pandemic, these therapies enable us to fight the most challenging diseases. The rapid and efficient design as well as optimization of the bioprocesses used for the production of these therapeutics and bridging the significant gap between small-scale experiments to clinical and commercial manufacturing scales have become a priority across the world.

The fast-growing literature on the use of computational fluid dynamics (CFD) for process design and scale-up reflects the rapid growth of using this tool in the field of biopharmaceuticals. CFD enables scientists to generate a digital copy of the process and can potentially capture the interactions between biological and transport phenomena and the associated non-linearities across reactor scales. These in silico tools can provide new insights into process attributes, reduce the number of experiments, increase process robustness, reduce risks associated with scale-up, and, therefore, result in the faster and cheaper production of therapeutics.

This Special Issue will focus on recent advances in the application of CFD for the design and optimization of upstream, downstream, filling, and finishing unit operations in biopharmaceutical processes.

Topics include, but are not limited to, the following:

• Novel bioreactor and mixing unit design and optimization.
• Purification of therapeutics.
• Multiphysics and multiscale CFD models.
• Coupling CFD with biological models.

Dr. Behnam Partopour
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• CFD
• biopharmaceutical
• advanced therapies
• design and optimization
• multiscale modeling
• digital twins