Analytical Methodologies and Stability Assessment of Bioactive Compounds in Complex Matrices
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Separation Processes".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 454
Special Issue Editor
Interests: chromatographic techniques; methods validation; drug analysis; stability testing; interactions; drug impurities; remediation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Analytical methods used to analyze bioactive compounds in complex matrices utilize specialized techniques such as high-performance liquid chromatography (HPLC), gas chromatography, and thin-layer chromatography, coupled with various detectors. The methodology is preceded by advanced sample preparation, including microextraction techniques (i.e., SPE, UASE). The complexity of matrices such as blood, plasma, urine, plant material, or food requires highly selective and sensitive analytical methods to avoid matrix interferences. Assessing the stability of compounds involves analyzing the impact of various environmental conditions on their degradation process over time. The obtained results allow us to identify potential degradation pathways, ensuring the authenticity and purity of the products. To ensure the reliability of the results, validation of the methods used is necessary, including checking linearity, precision, accuracy, and limits of detection and quantification. An important condition for modern analytical procedures is also the issue of developing sustainable and environmentally friendly methods (‘Green Chemistry’), using, for example, ecological solvents for extraction.
This Special Issue may constitute a review of works that meet the above assumptions and will allow for the characterization of active substances, including origin, production methods, extraction methods and chemical and/or microbiological composition, using validated analytical methods. We invite authors of papers from various scientific disciplines for whom the value of the finished product (drug, dietary supplement, food, etc.) is important from the point of view of the declared and expected health effect.
Dr. Malgorzata Starek
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- analytical techniques
- chromatography
- extraction
- matrix effects
- biological material
- drugs
- dietary supplements
- compound stability
- degradation
- method validation
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