Analytical Methodologies and Stability Assessment of Bioactive Compounds in Complex Matrices

Dear Colleagues,

Analytical methods used to analyze bioactive compounds in complex matrices utilize specialized techniques such as high-performance liquid chromatography (HPLC), gas chromatography, and thin-layer chromatography, coupled with various detectors. The methodology is preceded by advanced sample preparation, including microextraction techniques (i.e., SPE, UASE). The complexity of matrices such as blood, plasma, urine, plant material, or food requires highly selective and sensitive analytical methods to avoid matrix interferences. Assessing the stability of compounds involves analyzing the impact of various environmental conditions on their degradation process over time. The obtained results allow us to identify potential degradation pathways, ensuring the authenticity and purity of the products. To ensure the reliability of the results, validation of the methods used is necessary, including checking linearity, precision, accuracy, and limits of detection and quantification. An important condition for modern analytical procedures is also the issue of developing sustainable and environmentally friendly methods (‘Green Chemistry’), using, for example, ecological solvents for extraction.

This Special Issue may constitute a review of works that meet the above assumptions and will allow for the characterization of active substances, including origin, production methods, extraction methods and chemical and/or microbiological composition, using validated analytical methods. We invite authors of papers from various scientific disciplines for whom the value of the finished product (drug, dietary supplement, food, etc.) is important from the point of view of the declared and expected health effect.

Dr. Malgorzata Starek
Guest Editor

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