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Polymer-Based Material for Tissue Engineering

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (5 December 2022) | Viewed by 2693

Special Issue Editor


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Guest Editor
Polymeric Biomaterials Laboratory (Poli-BIO), Institute of Chemistry, Universidade Federal do Rio grande do Sul (UFRGS), Porto Alegre, Brazil
Interests: biomaterials; polymeric biomaterials; biomaterial science; biodegradable polymers; 3D printing
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Special Issue Information

Dear Colleagues,

The interdisciplinary field of biomaterials and polymers science has been one of the most rapidly expanding interdisciplinary fields during the past three decades. Polymeric biomaterials and their chemical structures play key roles in biological systems by providing support, acting as tissue replacements, and facilitating therapy or drug delivery. Accordingly, several techniques for polymer processing have been developed to provide a three-dimensional template for tissue growth and regeneration. 3D printing and stimuli-responsive hydrogels may have an impact in the biomedical field. Meanwhile, biomimetic and intelligent polymeric systems have also been investigated regarding their potential in tissue engineering. Hence, cell–material interactions, the chemical structure of polymers, porous microstructures, and the design of biomaterials are tunable properties that will define the impact of these substances in the biomedical field.

We invite authors to submit original research articles as well as review articles to share developments in natural and synthetic polymers for tissue engineering purposes. Of particular interest for this Special Issue are stimuli-responsive hydrogels, biomimetic materials, and hydrogel-based bioinks for use in 3D printing.

Sincerely,

Dr. Rosane Michele Duarte Soares
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

tissue engineering; natural and synthetic polymers; stimuli-responsive hydrogels; biomimetic materials; hydrogel-based bioinks for 3D printing

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Published Papers (1 paper)

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Research

18 pages, 4080 KiB  
Article
Cytostatic Effects of Polyethyleneimine Surfaces on the Mesenchymal Stromal Cell Cycle
by Anna Alba, Giusy Villaggio, Grazia Maria Lucia Messina, Massimo Caruso, Concetta Federico, Maria Teresa Cambria, Giovanni Marletta and Fulvia Sinatra
Polymers 2022, 14(13), 2643; https://doi.org/10.3390/polym14132643 - 29 Jun 2022
Cited by 5 | Viewed by 1987
Abstract
Polyelectrolytes assembled layer-by-layer (PEMs) are commonly used as functional coatings to build-up biological interfaces, particularly suitable as compatible layers for the interaction with a biological medium, providing suitable conditions to promote or prevent cell seeding while maintaining the phenotype. The proper assessment of [...] Read more.
Polyelectrolytes assembled layer-by-layer (PEMs) are commonly used as functional coatings to build-up biological interfaces, particularly suitable as compatible layers for the interaction with a biological medium, providing suitable conditions to promote or prevent cell seeding while maintaining the phenotype. The proper assessment of the biocompatibility of PEMs and the elucidation of the related mechanisms are therefore of paramount importance. In this study, we report in detail the effect of two different PEM endings, polystyrene sulfonate (PSS) and polyethylenimine (PEI), respectively, on the cell adhesion, growth, and viability of human bone mesenchymal stromal cells (MSCs). The results have shown that PSS-ended substrates appear to be the most suitable to drive the cell adhesion and phenotype maintenance of MSCs, showing good biocompatibility. On the contrary, while the cells seem to adhere more quickly and strongly on the PEI-ended surfaces, the interaction with PEI significantly affects the growth and viability, reducing the cell spreading capability, by sequestering the adhesion molecules already in the very early steps of cell–substrate contact. These results point to the promotion of a cytostatic effect of PEI, rather than the often-claimed cytotoxicity. Full article
(This article belongs to the Special Issue Polymer-Based Material for Tissue Engineering)
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