Special Issue "Advanced Biopolymers for Tissue Engineering Application"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 20 July 2023 | Viewed by 603

Special Issue Editor

Department of Chemistry and Technology of Polymer Materials and Nanocomposites, The Kosygin State University of Russia, 119071 Moscow, Russia
Interests: biodegradable polymers; polysaccharides; chitosan; bio-based polymeric materials; hydrogels; tissue engineering and regeneration; drug delivery systems

Special Issue Information

Dear Colleagues,

Tissue engineering can solve many problems of regenerative medicine, with the capacity to improve the duration and quality of human life by restoring the lost structure and function of organs and tissues. The main task of tissue engineering and regenerative medicine is to develop an optimal biodegradable polymer scaffold (matrix), ensuring cell adhesion and proliferation. This must be gradually replaced by forming tissues or organs. The main requirements that are imposed on polymer scaffolds are biological compatibility, a large porous structure that supports migration and settlement (adhesion) while boosting cell life, and a complex of mechanical and physicochemical properties (elasticity, atraumaticity, water swelling ability, adhesion characteristics). The matrix should resorb in the body after performing the function of a temporary framework that supports the growth and proliferation of cells and the formation of new tissues based on it. Therefore, biodegradable polymers are used as biomaterials to create scaffolds, and the choice of polymer is determined by its biomechanical compatibility with the resorbed tissue. Materials used in soft tissue replacement surgery should have a high water-retaining capacity. Therefore, from the point of view of biomimetics, the use of polysaccharide hydrogels is preferable over hydrophobic biodegradable polyesters. Conversely, due to their mechanical strength and osteoconductive properties, composite materials based on polyhydroxyalkanoates and inorganic phosphates are considered promising for bone replacement. High porosity and the required pore size in scaffolds are the main conditions for ensuring cell colonization and proliferation, and now various advanced technologies are adopting to build porous scaffolds for regenerating organs and tissues for suitable application in the tissue engineering.

The Special Issue, entitled “Advanced Biopolymers Application in Tissue Engineering”, aims to provide a platform for the communication and fast publication of high-quality original and review papers These should span topics like the development of biopolymer scaffolds, hydrogels, polymer-based composites, and formation methods of porous structures.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • Biopolymers for tissue engineering and regeneration (chitin, chitosan, fibroin, collagens polylactic acid, polyhydroxyalkanoates and so on);
  • Bio-based polymeric materials: polysaccharide hydrogels, composites and hybrid materials;
  • Formation methods of biopolymer matrices porous structures such as cryotropic gelation and 3D printing;
  • The relationship in biopolymeric scaffold between "structure-morphology" and "morphology-properties";
  • New technologies of forming biomaterials for tissue engineering;
  • Biopolymer-based drug delivery systems in regenerative medicine;
  • Methods for evaluating biocompatibility and effectiveness of application as an artificial matrix for tissue engineering of bio-based polymer materials.

Prof. Dr. Nataliya Kildeeva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biodegradable polymers
  • biomaterials
  • bio-based composites
  • drug delivery
  • hydrogels
  • scaffolds
  • tissue engineering

Published Papers (1 paper)

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Composite Hydrogels Based on Cross-Linked Chitosan and Low Molecular Weight Hyaluronic Acid for Tissue Engineering
Polymers 2023, 15(10), 2371; https://doi.org/10.3390/polym15102371 - 19 May 2023
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The objectives of the study were as follows: (1) to develop two methods for the preparation of macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels based on covalently cross-linked Ch and low molecular weight (Mw) HA (5 and 30 kDa); (2) to investigate some properties [...] Read more.
The objectives of the study were as follows: (1) to develop two methods for the preparation of macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels based on covalently cross-linked Ch and low molecular weight (Mw) HA (5 and 30 kDa); (2) to investigate some properties (swelling and in vitro degradation) and structures of the hydrogels; (3) to evaluate the hydrogels in vitro as potential biodegradable matrices for tissue engineering. Chitosan was cross-linked with either genipin (Gen) or glutaraldehyde (GA). Method 1 allowed the distribution of HA macromolecules within the hydrogel (bulk modification). In Method 2, hyaluronic acid formed a polyelectrolyte complex with Ch over the hydrogel surface (surface modification). By varying compositions of the Ch/HA hydrogels, highly porous interconnected structures (with mean pore sizes of 50–450 μm) were fabricated and studied using confocal laser scanning microscopy (CLSM). Mouse fibroblasts (L929) were cultured in the hydrogels for 7 days. Cell growth and proliferation within the hydrogel samples were studied via MTT-assay. The entrapment of low molecular weight HA was found to result in an enhancement of cell growth in the Ch/HA hydrogels compared to that in the Ch matrices. The Ch/HA hydrogels after bulk modification promoted better cell adhesion, growth and proliferation than the samples prepared by using Method 2 (surface modification). Full article
(This article belongs to the Special Issue Advanced Biopolymers for Tissue Engineering Application)
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