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Antimicrobial Properties of Polymers and Polypeptides

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 1629

Special Issue Editors


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Guest Editor
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: antimicrobial peptide; virus-host interaction; zoonoses; animal viruses; respiratory viruses
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Guest Editor
Institute of Biostructures and Bioimaging (IBB), National Research Council (CNR), 80134 Naples, Italy
Interests: peptides; peptidomimetics

Special Issue Information

Dear Colleagues,

The recent pandemic outbreaks have highlighted the possible spread of infectious diseases caused by emerging and re-emerging pathogens, representing a very serious public health problem. Furthermore, the rise of antimicrobial resistance and the scarcity of drugs able to eradicate microbial infections have determined the urgent need to propose and develop alternative therapeutic strategies. In this regard, the use of ad hoc developed polymers, antimicrobial peptides and small molecules could represent a valuable opportunity to address this need.

This Special Issue aims to collect original contributions and reviews that delve into the most recent results on the development of polymeric materials, peptides and peptidomimetics with antimicrobial activity and the elucidation of their mechanisms of action at the molecular level in microbes, such as bacteria, viruses, yeasts, fungi and parasites. Additionally, this issue welcomes papers describing the impact of antimicrobial agents in the fields of food packaging, biomedical, healthcare and environmental materials, taking into account their potentials and pitfalls.

Dr. Annalisa Chianese
Dr. Nunzianna Doti
Dr. Alessandra Monti
Guest Editors

Manuscript Submission Information

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Keywords

  • antiviral
  • antibacterial
  • polymers
  • peptides
  • infectious diseases

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Published Papers (2 papers)

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Research

18 pages, 10560 KiB  
Article
Copper Nanoparticle Loaded Electrospun Patches for Infected Wound Treatment: From Development to In-Vivo Application
by Anna Butsyk, Yulia Varava, Roman Moskalenko, Yevheniia Husak, Artem Piddubnyi, Anastasiia Denysenko, Valeriia Korniienko, Agne Ramanaviciute, Rafal Banasiuk, Maksym Pogorielov, Arunas Ramanavicius and Viktoriia Korniienko
Polymers 2024, 16(19), 2733; https://doi.org/10.3390/polym16192733 - 27 Sep 2024
Viewed by 330
Abstract
This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, and copper nanoparticles (CuNPs) for the treatment of purulent skin wounds. The materials were evaluated for their structural, antibacterial, and wound healing properties using an [...] Read more.
This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, and copper nanoparticles (CuNPs) for the treatment of purulent skin wounds. The materials were evaluated for their structural, antibacterial, and wound healing properties using an animal model. PLA/Ch-CuNPs demonstrated the most significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, surpassing the other tested materials. The integration of CuNPs into the nanofiber matrices not only enhanced the antimicrobial efficacy but also maintained the structural integrity and biocompatibility of the dressings. In vivo experiments using a rat model showed that PLA/Ch-CuNPs facilitated faster wound healing with reduced exudative and inflammatory responses compared to PLA alone or PLA-CuNPs. Histological and immunohistochemical assessments revealed that the combination of PLA, chitosan, and CuNPs mitigated the inflammatory processes and promoted tissue regeneration more effectively. However, this study identified potential toxicity related to copper ions, emphasizing the need for careful optimization of CuNP concentrations. These findings suggest that PLA/Ch-CuNPs could serve as a potent, cost-effective wound dressing with broad-spectrum antibacterial properties, addressing the challenge of antibiotic-resistant infections and enhancing wound healing outcomes. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Polymers and Polypeptides)
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18 pages, 5346 KiB  
Article
Revealing Commercial Epoxy Resins’ Antimicrobial Activity: A Combined Chemical–Physical, Mechanical, and Biological Study
by Mario Rigo, Hamoun Khatami, Antonella Mansi, Anna Maria Marcelloni, Anna Rita Proietto, Alessandra Chiominto, Ilaria Amori, Annalisa Bargellini, Isabella Marchesi, Giuseppina Frezza, Francesco Lipani, Claudio Cermelli, Angelo Rossini, Marino Quaresimin, Michele Zappalorto, Alessandro Pontefisso, Matteo Pastrello, Daniele Rossetto, Michele Modesti, Paolo Sgarbossa and Roberta Bertaniadd Show full author list remove Hide full author list
Polymers 2024, 16(18), 2571; https://doi.org/10.3390/polym16182571 - 11 Sep 2024
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Abstract
In our continuing search for new polymer composites with antimicrobial activity, we observed that even unmodified epoxy resins exhibit significant activity. Considering their widespread use as starting materials for the realization of multifunctional nanocomposites with excellent chemical and mechanical properties, it was deemed [...] Read more.
In our continuing search for new polymer composites with antimicrobial activity, we observed that even unmodified epoxy resins exhibit significant activity. Considering their widespread use as starting materials for the realization of multifunctional nanocomposites with excellent chemical and mechanical properties, it was deemed relevant to uncover these unexpected properties that can lead to novel applications. In fact, in places where the contact with human activities makes working surfaces susceptible to microbial contamination, thus jeopardizing the sterility of the environment, their biological activity opens the way to their successful application in minimizing healthcare-associated infections. To this end, three commercial and widely used epoxy resins (DGEBA/Elan-TechW 152LR, 1; EPIKOTETM Resin MGS®/EPIKURETM RIM H 235, 2 and MC152/EW101, 3) have been investigated to determine their antibacterial and antiviral activity. After 24 h, according to ISO 22196:2011, resins 1 and 2 showed a high antibacterial efficacy (R value > 6.0 log reduction) against Staphylococcus aureus and Escherichia coli. Resin 2, prepared according to the ratio epoxy/hardener indicated by the supplier (sample 2a) and with 10% w/w hardener excess (sample 2b), exhibited an intriguing virucidal activity against Herpes Simplex Virus type-1 and Human Coronavirus type V-OC43 as a surrogate of SARS-CoV-2. Full article
(This article belongs to the Special Issue Antimicrobial Properties of Polymers and Polypeptides)
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