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Polymers
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Polymers for Drug/Gene Delivery and Controlled Release
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Polymers for Drug/Gene Delivery and Controlled Release

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 923

Special Issue Editor

Dr. Guobin Ding

E-Mail Website
Guest Editor
Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China
Interests: polymer-based nanomedicine; polymers for tumor-targeted drug delivery; antitumor protein; siRNA delivery; polymers for antitumor therapy; tumor acidic microenvironment

Special Issue Information

Dear Colleagues,

This Special Issue of Polymers, entitled "Polymers for Drug/Gene Delivery and Controlled Release", aims to showcase cutting-edge research in the intersection of polymer science and pharmaceutical technology. This Special Issue aims to provide a platform for researchers to present their innovative work on the development and application of polymers for enhanced drug/gene delivery systems and controlled release mechanisms.

Contributions are sought in areas encompassing the design of novel polymer-based drug delivery vehicles, the use of advanced materials for targeted drug/gene release, biocompatibility studies of polymer carriers, and the incorporation of stimuli-responsive polymers for on-demand drug/gene delivery. Furthermore, research exploring the synergistic relationships between polymers and drug formulations to optimize therapeutic efficacy and minimize side effects is encouraged.

This Special Issue invites submissions that push the boundaries of drug/gene delivery technologies, offering a valuable resource for researchers, practitioners, and industry professionals invested in advancing drug delivery strategies for improved patient outcomes.

Dr. Guobin Ding
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based drug delivery
  • gene delivery
  • controlled release mechanisms
  • stimuli-responsive polymers
  • targeted drug delivery systems
  • biocompatible polymer carriers
  • therapeutic efficacy optimization
  • gene therapy
  • drug delivery vehicles
  • pharmaceutical polymer technology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 2005 KiB  
Article
Quantification of Hydrogen Peroxide in PVP and PVPVA Using 1H qNMR Spectroscopy
by Isha Saraf, Varun Kushwah, Bernd Werner, Klaus Zangger and Amrit Paudel
Polymers 2025, 17(6), 739; https://doi.org/10.3390/polym17060739 - 11 Mar 2025
Viewed by 537
Abstract
Objective: Peroxides in pharmaceutical products and excipients pose risks by oxidizing drug molecules, leading to potential toxicity and reduced efficacy. Accurate peroxide quantification is essential to ensure product safety and potency. This study explores the use of quantitative proton nuclear magnetic resonance ( [...] Read more.
Objective: Peroxides in pharmaceutical products and excipients pose risks by oxidizing drug molecules, leading to potential toxicity and reduced efficacy. Accurate peroxide quantification is essential to ensure product safety and potency. This study explores the use of quantitative proton nuclear magnetic resonance (1H qNMR) spectroscopy as a sensitive and specific method for quantifying peroxide levels in pharmaceutical excipients. Methods: 1H qNMR spectroscopy was employed to measure peroxide levels down to 0.1 ppm in excipients, focusing on poly(vinylpyrrolidone) (PVP) and polyvinylpyrrolidone/vinyl acetate (PVPVA). Different grades and vendors were analyzed, and the impact of various manufacturing processes on hydrogen peroxide content was examined. Results: Peroxide levels varied among different grades of PVP and PVPVA, as well as between vendors. Furthermore, manufacturing processes influenced the hydrogen peroxide content in selected excipients. These variations highlight the importance of controlling peroxide levels in raw materials and during production. Conclusions: 1H qNMR spectroscopy is a valuable tool for accurately quantifying peroxide levels in pharmaceutical excipients. The study emphasizes the need for regular monitoring of peroxide content to ensure the stability, quality, and safety of excipients and drug products. Accurate peroxide measurement can prevent oxidative degradation, preserving both the safety and efficacy of pharmaceutical formulations. Full article
(This article belongs to the Special Issue Polymers for Drug/Gene Delivery and Controlled Release)
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