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Polymers
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Polymers for Drug/Gene Delivery and Controlled Release
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Polymers for Drug/Gene Delivery and Controlled Release

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 5937

Special Issue Editor

Dr. Guobin Ding

E-Mail Website
Guest Editor
Institutes of Biomedical Sciences, School of Life Sciences, Inner Mongolia University, Hohhot 010070, China
Interests: polymer-based nanomedicine; polymers for tumor-targeted drug delivery; antitumor protein; siRNA delivery; polymers for antitumor therapy; tumor acidic microenvironment

Special Issue Information

Dear Colleagues,

This Special Issue of Polymers, entitled "Polymers for Drug/Gene Delivery and Controlled Release", aims to showcase cutting-edge research in the intersection of polymer science and pharmaceutical technology. This Special Issue aims to provide a platform for researchers to present their innovative work on the development and application of polymers for enhanced drug/gene delivery systems and controlled release mechanisms.

Contributions are sought in areas encompassing the design of novel polymer-based drug delivery vehicles, the use of advanced materials for targeted drug/gene release, biocompatibility studies of polymer carriers, and the incorporation of stimuli-responsive polymers for on-demand drug/gene delivery. Furthermore, research exploring the synergistic relationships between polymers and drug formulations to optimize therapeutic efficacy and minimize side effects is encouraged.

This Special Issue invites submissions that push the boundaries of drug/gene delivery technologies, offering a valuable resource for researchers, practitioners, and industry professionals invested in advancing drug delivery strategies for improved patient outcomes.

Dr. Guobin Ding
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer-based drug delivery
  • gene delivery
  • controlled release mechanisms
  • stimuli-responsive polymers
  • targeted drug delivery systems
  • biocompatible polymer carriers
  • therapeutic efficacy optimization
  • gene therapy
  • drug delivery vehicles
  • pharmaceutical polymer technology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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14 pages, 2005 KB  
Article
Quantification of Hydrogen Peroxide in PVP and PVPVA Using 1H qNMR Spectroscopy
by Isha Saraf, Varun Kushwah, Bernd Werner, Klaus Zangger and Amrit Paudel
Polymers 2025, 17(6), 739; https://doi.org/10.3390/polym17060739 - 11 Mar 2025
Cited by 2 | Viewed by 2485
Abstract
Objective: Peroxides in pharmaceutical products and excipients pose risks by oxidizing drug molecules, leading to potential toxicity and reduced efficacy. Accurate peroxide quantification is essential to ensure product safety and potency. This study explores the use of quantitative proton nuclear magnetic resonance ( [...] Read more.
Objective: Peroxides in pharmaceutical products and excipients pose risks by oxidizing drug molecules, leading to potential toxicity and reduced efficacy. Accurate peroxide quantification is essential to ensure product safety and potency. This study explores the use of quantitative proton nuclear magnetic resonance (1H qNMR) spectroscopy as a sensitive and specific method for quantifying peroxide levels in pharmaceutical excipients. Methods: 1H qNMR spectroscopy was employed to measure peroxide levels down to 0.1 ppm in excipients, focusing on poly(vinylpyrrolidone) (PVP) and polyvinylpyrrolidone/vinyl acetate (PVPVA). Different grades and vendors were analyzed, and the impact of various manufacturing processes on hydrogen peroxide content was examined. Results: Peroxide levels varied among different grades of PVP and PVPVA, as well as between vendors. Furthermore, manufacturing processes influenced the hydrogen peroxide content in selected excipients. These variations highlight the importance of controlling peroxide levels in raw materials and during production. Conclusions: 1H qNMR spectroscopy is a valuable tool for accurately quantifying peroxide levels in pharmaceutical excipients. The study emphasizes the need for regular monitoring of peroxide content to ensure the stability, quality, and safety of excipients and drug products. Accurate peroxide measurement can prevent oxidative degradation, preserving both the safety and efficacy of pharmaceutical formulations. Full article
(This article belongs to the Special Issue Polymers for Drug/Gene Delivery and Controlled Release)
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Review

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21 pages, 4278 KB  
Review
Recent Advances in Multimodal Nanostructured Bioaerogels for Smart Drug Delivery
by Muhanad A. Abdulsamad, Lujin A. Essa, Rabia Alghazeer, Norah Alkhayyal, Rawan Altalhi, Randah Alghamdi and Esam Bashir Yahya
Polymers 2025, 17(22), 3012; https://doi.org/10.3390/polym17223012 - 12 Nov 2025
Viewed by 744
Abstract
The convergence of nanotechnology and bioaerogels has paved the way for the development of multimodal nanostructured bioaerogels with remarkable potential in smart drug delivery systems. These advanced biomaterials integrate multiple functionalities, including sensing, targeting, and therapeutic actions, to enhance drug efficacy, minimize systemic [...] Read more.
The convergence of nanotechnology and bioaerogels has paved the way for the development of multimodal nanostructured bioaerogels with remarkable potential in smart drug delivery systems. These advanced biomaterials integrate multiple functionalities, including sensing, targeting, and therapeutic actions, to enhance drug efficacy, minimize systemic side effects, and enable real-time monitoring of therapeutic responses. This review provides a comprehensive analysis of the structural design, physicochemical properties, and fabrication strategies of multimodal bioaerogels. It further explores their role in responsive drug delivery, emphasizing stimuli-responsive mechanisms such as pH, temperature, and enzymatic triggers. The incorporation of nanomaterials, including metallic nanoparticles, carbon-based nanostructures, and polymeric nanocarriers, has endowed bioaerogels with tunable porosity, controlled drug release, and bioactive functionalities. Additionally, their application in precision medicine, particularly for cancer therapy, antimicrobial treatments, and tissue engineering, is critically examined. Challenges related to scalability, biocompatibility, and regulatory compliance are also discussed, alongside future perspectives on advancing these bioaerogels toward clinical translation. By integrating interdisciplinary insights, this review underscores the transformative potential of multimodal nanostructured bioaerogels in the next generation of intelligent drug delivery systems. Full article
(This article belongs to the Special Issue Polymers for Drug/Gene Delivery and Controlled Release)
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33 pages, 2450 KB  
Review
Research Progress on Polymer-Based Nanocarriers for Tumor-Targeted Delivery of Survivin siRNA
by Luya Ren, Shaoxia Wang, Bin-Chun Li and Guo-Bin Ding
Polymers 2025, 17(17), 2279; https://doi.org/10.3390/polym17172279 - 23 Aug 2025
Viewed by 2042
Abstract
Survivin, a pivotal member of the inhibitor of apoptosis proteins (IAP) family, plays critical roles in cell cycle regulation and division. Survivin is overexpressed in most malignancies, making it an attractive therapeutic target. Due to its high specificity and potency, siRNA-based RNA interference [...] Read more.
Survivin, a pivotal member of the inhibitor of apoptosis proteins (IAP) family, plays critical roles in cell cycle regulation and division. Survivin is overexpressed in most malignancies, making it an attractive therapeutic target. Due to its high specificity and potency, siRNA-based RNA interference (RNAi) has emerged as a powerful therapeutic strategy for effectively downregulating disease-related genes such as survivin in cancer therapy. However, naked siRNA suffers from rapid enzymatic degradation, poor cellular uptake, and off-target effects, severely limiting its therapeutic efficacy in vivo. Development of polymer-based nanocarriers for tumor-targeted delivery of survivin siRNA (siSurvivin) holds great potential to address these challenges. In this review, we first described the structure and function of survivin and summarized the survivin-targeted therapeutic strategy. Then, the siRNA delivery systems, particularly the polymeric nanocarriers, were introduced. Furthermore, a plethora of polymer-based nanocarriers for tumor-targeted siSurvivin delivery, including synthetic polymers (branched polymers, dendritic polymers, polymeric micelles), natural polymers (polysaccharides, proteins, and others), lipid-polymer hybrid nanoparticles, and polymer composite nanoparticles, were elaborated. Promising results underscore the potential of polymer-based nanocarriers for survivin siRNA delivery to enhance cancer therapy, providing a roadmap for future clinical translation. Full article
(This article belongs to the Special Issue Polymers for Drug/Gene Delivery and Controlled Release)
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