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Synthetic-Biological Hybrid Polymers and Co-Assembled Nanostructures

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1597

Special Issue Editors


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Guest Editor
Petru Poni Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania
Interests: complex multicomponent systems; natural and synthetic polymers; functional polymers; functionalization of polymers; nanostructures; hybrids; electrostatic self-assembly
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Guest Editor
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., 11635 Athens, Greece
Interests: synthesis of amphiphilic block copolymers and polyelectrolytes by controlled polymerizations; macromolecular assemblies; hybrid polymer-based nanostructures; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymeric materials have been instrumental in the development of current technology and applications in everyday life. For many years, synthetic polymers have been the focus of scientific and technological developments. Block copolymers and polyelectrolytes are being intensively studied due to their ability to self- or co-assemble into nanoscale objects of different morphologies, sensitive to external stimuli (pH, temperature, ionic strength, light, etc.). At present, there is a strong need for polymeric materials from more sustainable sources: in this context, polysaccharides, as an important and abundant class of biomacromolecules, can be the answer. Natural biopolymers can be chemically modified thanks to the presence of numerous free functional groups displayed along their backbones. Their self- and co-assembly processes, following principles from the physical chemistry of synthetic polymers, provide self-organized nanoassemblies that could find applications as nanocarriers (for drugs and dyes, therapeutic biomacromolecules/proteins, peptides, nucleic acids, inorganic nanoparticles), nanocontainers (for water organic/inorganic pollutants), surface functionalization nanomaterials, and so on. As the proposed topic is remarkably interesting, we invite you and your research team to submit research or review articles to this Special Issue entitled Synthetic-Biological Hybrid Polymers and Co-Assembled Nanostructures that will be published in the Polymers journal.

Dr. Marcela Mihai
Dr. Asterios (Stergios) Pispas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polysaccharide modification
  • hybrid macromolecules
  • self-assembled nanostructures
  • co-assembly
  • nanocarriers
  • nanocontainers
  • surface functionalization

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Published Papers (2 papers)

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Research

18 pages, 2357 KB  
Article
Chitosan-Based Cast Films of Different Molecular Weights for Sustained Activity of Bacillus subtilis
by Vladimir Krastev, Nikoleta Stoyanova, Iliyana Valcheva, Donka Draganova, Mariya Spasova and Olya Stoilova
Polymers 2026, 18(7), 784; https://doi.org/10.3390/polym18070784 - 24 Mar 2026
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Abstract
The development of sustainable plant protection strategies requires stable and environmentally compatible delivery systems for beneficial microorganisms. In this study, Bacillus subtilis was encapsulated within chitosan-based cast films to evaluate bacterial viability, sustained biological activity, and antifungal efficacy. Films prepared from chitooligosaccharide (COS) [...] Read more.
The development of sustainable plant protection strategies requires stable and environmentally compatible delivery systems for beneficial microorganisms. In this study, Bacillus subtilis was encapsulated within chitosan-based cast films to evaluate bacterial viability, sustained biological activity, and antifungal efficacy. Films prepared from chitooligosaccharide (COS) and chitosans of low, medium, and high molecular weight (CS-LMW, CS-MMW, CS-HMW) were characterized in terms of morphology, mechanical performance, and pH-dependent swelling behavior. The viscosity of the chitosan solutions increased markedly with molecular weight from 73 cP (COS) to 614 cP (CS-HMW), while film thickness ranged from 34 ± 1.5 to 57 ± 2.3 µm. Mechanical performance improved significantly with increasing molecular weight, with maximum tensile stress exceeding 200 MPa for CS-HMW films, while swelling studies confirmed pronounced pH-dependent behavior consistent with the polyelectrolyte nature of chitosan. Encapsulation effectively preserved bacterial viability and metabolic activity over time. The intrinsic antifungal activity of chitosan synergized with the biocontrol activity of B. subtilis against Fusarium avenaceum and Alternaria solani. The highest antifungal performance was observed for CS-HMW films, which produced inhibition zones up to 84.6 ± 5.0 mm against A. solani. These findings demonstrate that chitosan-based cast films serve as effective carriers for beneficial microorganisms, providing environmental protection and regulated biological activity. The combination of a bioactive polymer matrix with a potent biocontrol agent represents a promising eco-friendly approach to sustainable plant protection. Full article
(This article belongs to the Special Issue Synthetic-Biological Hybrid Polymers and Co-Assembled Nanostructures)
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16 pages, 3073 KB  
Article
Self-Assembled (Nano)Structures of Human Serum Albumin with Thermoresponsive Chitosan-g-PNIPAM Graft Copolymer
by Florin Bucatariu, Larisa-Maria Petrila, Timeea-Anastasia Ciobanu, Marius-Mihai Zaharia, Stergios Pispas and Marcela Mihai
Polymers 2026, 18(4), 515; https://doi.org/10.3390/polym18040515 - 19 Feb 2026
Viewed by 541
Abstract
Protein–polyelectrolyte entities (complex, coacervates, flocs, gels, etc.) are of great interest due to their potential applications in biological and medical fields. This study focuses on investigating the interactions between a model protein, human serum albumin (HSA) and a newly synthesized hybrid thermoresponsive copolymer [...] Read more.
Protein–polyelectrolyte entities (complex, coacervates, flocs, gels, etc.) are of great interest due to their potential applications in biological and medical fields. This study focuses on investigating the interactions between a model protein, human serum albumin (HSA) and a newly synthesized hybrid thermoresponsive copolymer based on chitosan polysaccharide grafted with poly(N-isopropylacrylamide) synthetic polymer chains (Chit-g-PNIPAM), in aqueous media, by mixing the individual component aqueous solutions. Depending on the mixing molar ratio and the order of addition of the two components (protein and copolymer), either stable nanostructured suspension or macrostructures’ phase separation have been observed. Dynamic light scattering (DLS) results reveal that the Chit-g-PNIPAM/HSAx (molar ratio 5:x, where x = 1, 2, 3, 5, 10 and 15) nanostructures’ and HSA/Chit-g-PNIPAMx (molar ratio 100:x, where x = 1, 2, 3, 10, 20, 30, 40 and 50) structures’ formation depend on the molar ratio of the two components as well as on the order of addition, with first component amount being kept constant in aqueous solution and second component solution added drop-by-drop in the solution of the first component. Additional information regarding the thermoresponsiveness and stability vs time of the formed (nano)structures were acquired using turbidimetry and DLS measurements. Full article
(This article belongs to the Special Issue Synthetic-Biological Hybrid Polymers and Co-Assembled Nanostructures)
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