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Polymers
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Applications of Polymer Nanomaterials in Biomedicine
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Applications of Polymer Nanomaterials in Biomedicine

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Processing and Engineering".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 1756

Special Issue Editor

Dr. Wenhai Lin

E-Mail Website1 Website2
Guest Editor
College of Chemistry, Chemical Engineering and Materials Science, Soochow Univeristy, Suzhou, China
Interests: polymer; photosensitizer; drug delivery

Special Issue Information

Dear Colleagues,

Polymer nanomaterials play a vital role in biomedicine because of their following characteristics: improved targeting, reduced side effects, and excellent biocompatibility. To realize the diagnosis and treatment of diseases, polymer nanomaterials can load diagnostic reagents and drugs via chemical conjugation and physical encapsulation. In addition, these nanomaterials can be synthesized from polymers that possess theranostic capabilities on their own.

This Special Issue aims to cover the recent progress in and insights into polymer nanomaterials for disease imaging and treatment. Original research articles and reviews are welcome. The research areas may include (but are not limited to) the following: (1) novel polymer nanomaterials for drug delivery; (2) the synthesis of functional polymers for disease imaging and therapy; and (3) polymer drug delivery systems for combination therapy.

I look forward to receiving your contributions.

Dr. Wenhai Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer nanoparticles
  • drug delivery
  • chemotherapy
  • phototherapy
  • immunotherapy
  • nanomedicine
  • stimuli responsiveness
  • imaging
  • theranostics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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17 pages, 7161 KiB  
Article
High-Density Lipoprotein Biomimetic Inorganic–Organic Composite Nanosystem for Atherosclerosis Therapy
by Yunpeng Zhang, Danni Liu, Yaoqi Wang, Qi Sun, Dong Mei, Xiaoling Wang, Yan Su, Siyu Liu, Chunying Cui and Shuang Zhang
Polymers 2025, 17(5), 625; https://doi.org/10.3390/polym17050625 - 26 Feb 2025
Viewed by 548
Abstract
Atherosclerosis (AS) is an important causative agent of cardiovascular diseases, and the occurrence and development of AS is accompanied by oxidative stress, so antioxidant therapy has become one of the strategies for the treatment of AS. This study aimed to design and construct [...] Read more.
Atherosclerosis (AS) is an important causative agent of cardiovascular diseases, and the occurrence and development of AS is accompanied by oxidative stress, so antioxidant therapy has become one of the strategies for the treatment of AS. This study aimed to design and construct an apolipoprotein ApoA1-modified inorganic–organic composite nanosystem for AS therapy, in which ApoA1 was modified onto carboxylated CeO2/Mn3O4 by covalent bonding, resulting in an inorganic–organic nanocomplex with a structure similar to that of high-density lipoprotein. The nanocomplex could effectively deliver the antioxidant nanoparticles to the AS plaque through the specific recognition between ApoA1 and the macrophage at the AS lesion site. For one thing, the nanocomplex could alleviate the oxidative stress environment of the AS site through the highly efficient antioxidant effect of CeO2/Mn3O4, which played a therapeutic role in the treatment of AS. For another, it could effectively eliminate the formed lipid plaques and maximally alleviate and treat AS by utilizing the cholesterol efflux effect of ApoA1. Full article
(This article belongs to the Special Issue Applications of Polymer Nanomaterials in Biomedicine)
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Review

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54 pages, 7608 KiB  
Review
Development of Stimuli-Responsive Polymeric Nanomedicines in Hypoxic Tumors and Their Therapeutic Promise in Oral Cancer
by Jialong Hou, Zhijun Xue, Yao Chen, Jisen Li, Xin Yue, Ying Zhang, Jing Gao, Yonghong Hao and Jing Shen
Polymers 2025, 17(8), 1010; https://doi.org/10.3390/polym17081010 - 9 Apr 2025
Viewed by 508
Abstract
Hypoxic tumors pose considerable obstacles to cancer treatment, as diminished oxygen levels can impair drug effectiveness and heighten therapeutic resistance. Oral cancer, a prevalent malignancy, encounters specific challenges owing to its intricate anatomical structure and the technical difficulties in achieving complete resection, thereby [...] Read more.
Hypoxic tumors pose considerable obstacles to cancer treatment, as diminished oxygen levels can impair drug effectiveness and heighten therapeutic resistance. Oral cancer, a prevalent malignancy, encounters specific challenges owing to its intricate anatomical structure and the technical difficulties in achieving complete resection, thereby often restricting treatment efficacy. The impact of hypoxia is particularly critical in influencing both the treatment response and prognosis of oral cancers. This article summarizes and examines the potential of polymer nanomedicines to address these challenges. By engineering nanomedicines that specifically react to the hypoxic tumor microenvironment, these pharmaceuticals can markedly enhance targeting precision and therapeutic effectiveness. Polymer nanomedicines enhance therapeutic efficacy while reducing side effects by hypoxia-targeted accumulation. The article emphasizes that these nanomedicines can overcome the drug resistance frequently observed in hypoxic tumors by improving the delivery and bioavailability of anticancer agents. Furthermore, this review elucidates the design and application of polymer nanomedicines for treating hypoxic tumors, highlighting their transformative potential in cancer therapy. Finally, this article gives an outlook on stimuli-responsive polymeric nanomedicines in the treatment of oral cancer. Full article
(This article belongs to the Special Issue Applications of Polymer Nanomaterials in Biomedicine)
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