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Engineered Polymeric Particles for Next-Generation Nanomedicine

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 765

Special Issue Editor


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Guest Editor
1. Department of Biomaterials, Faculty of Medical Dentistry, “Apollonia” University of Iasi, 700511 Iasi, Romania
2. Academy of Romanian Scientists, 050045 Bucharest, Romania
Interests: block and graft copolymers; micelles; colloids; emulsions; drug delivery; polysaccharides
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advances in the design, synthesis, and application of polymeric particles engineered for cutting-edge nanomedicine. As polymer-based nanomaterials gain increasing attention for their versatility, biocompatibility, and tunable physicochemical properties, researchers are developing innovative strategies to overcome longstanding challenges in drug delivery, diagnostics, and regenerative medicine.

The issue highlights state-of-the-art methodologies for fabricating polymeric particles with controlled sizes, architectures, surface functionalities, and responsive behaviors. Contributions address emerging technologies such as stimuli-responsive polymers, bioinspired and biomimetic designs, hybrid polymer–inorganic systems, and advanced fabrication techniques including microfluidics and controlled self-assembly.

A central theme is the translation of these engineered particles into next-generation nanomedicine. Research and review articles examining their use in targeted and sustained drug delivery, gene and nucleic acid transport, immunomodulation, imaging and theranostics, minimally invasive treatments, and tissue engineering are of interest. In addition, special attention is given to the integration of specific ligand-functionalized polymeric nanocarriers for targeted therapy approaches, and smart polymer particles sensitive to different stimuli, such as pH, temperature, light, etc., from in vitro to in vivo investigations.

By bringing together interdisciplinary research from materials science, chemistry, biology, and clinical engineering, this Special Issue aims to provide a comprehensive overview of how engineered polymeric particles are shaping the future of nanomedicine. The insights presented here not only demonstrate the remarkable progress in the field, but also outline remaining challenges and promising directions for translating polymer-based nanotechnologies from the laboratory to real-world nanomedicine solutions.

Prof. Dr. Leonard Ionut Atanase
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymeric nano-microparticles
  • nanomedicine
  • drug delivery systems
  • targeted delivery
  • stimuli-responsive polymers
  • smart nanocarriers
  • biocompatible polymers
  • biomedical applications
  • theranostics
  • gene delivery
  • immunotherapy
  • controlled release
  • hybrid polymer–inorganic particles
  • biomimetic nanomaterials
  • tissue engineering
  • advanced nanomaterials

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Published Papers (1 paper)

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22 pages, 6931 KB  
Article
Biopolymer Casein–Pullulan Coating of Fe3O4 Nanocomposites for Xanthohumol Encapsulation and Delivery
by Nikolay Zahariev, Dimitar Penkov, Radka Boyuklieva, Plamen Simeonov, Paolina Lukova, Raina Ardasheva and Plamen Katsarov
Polymers 2026, 18(2), 256; https://doi.org/10.3390/polym18020256 - 17 Jan 2026
Viewed by 543
Abstract
Introduction: Magnetic nanoparticles are widely investigated as multifunctional platforms for drug delivery and theranostic applications, yet their biomedical implementation is hindered by aggregation, limited colloidal stability, and insufficient biocompatibility. Hybrid biopolymer coatings can mitigate these issues while supporting drug incorporation. Aim: This study [...] Read more.
Introduction: Magnetic nanoparticles are widely investigated as multifunctional platforms for drug delivery and theranostic applications, yet their biomedical implementation is hindered by aggregation, limited colloidal stability, and insufficient biocompatibility. Hybrid biopolymer coatings can mitigate these issues while supporting drug incorporation. Aim: This study aimed to develop casein–pullulan-coated Fe3O4 nanocomposites loaded with xanthohumol, enhancing stability and enabling controlled release for potential theranostic use. Methods: Fe3O4 nanoparticles were synthesized through co-precipitation and incorporated into a casein–pullulan matrix formed via polymer complexation and glutaraldehyde crosslinking. A 32 full factorial design evaluated the influence of casein:pullulan ratio and crosslinker concentration on physicochemical performance. Nanocomposites were characterized for size, zeta potential, morphology, composition, and stability, while drug loading, encapsulation efficiency, and release profiles were determined spectrophotometrically. Molecular docking was performed to examine casein–pullulan interactions. Results: Uncoated Fe3O4 nanoparticles aggregated extensively, displaying mean sizes of ~292 nm, zeta potential of +80.95 mV and high polydispersity (PDI above 0.2). Incorporation into the biopolymer matrix improved colloidal stability, yielding particles of ~185 nm with zeta potentials near –35 mV. TEM and SEM confirmed spherical morphology and uniform magnetic core incorporation. The optimal formulation, consisting of a 1:1 casein:pullulan ratio with 1% glutaraldehyde, achieved 5.7% drug loading, 68% encapsulation efficiency, and sustained release of xanthohumol up to 84% over 120 h, fitting Fickian diffusion (Korsmeyer–Peppas R2 = 0.9877, n = 0.43). Conclusions: Casein–pullulan hybrid coatings significantly enhance Fe3O4 nanoparticle stability and enable controlled release of xanthohumol, presenting a promising platform for future targeted drug delivery and theranostic applications. Full article
(This article belongs to the Special Issue Engineered Polymeric Particles for Next-Generation Nanomedicine)
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