Natural Compounds Found in Plants and Their Anti-Inflammatory and Antinociceptive Mechanisms: Implications for Human Health

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 1702

Special Issue Editors


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Guest Editor
Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife CEP 50670-901, Pernambuco, Brazil
Interests: anti-inflammatory; natural products; oxidative stress; antioxidant defense; digestive disorders; aromatic plants; essential oils; bioactive molecules

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Guest Editor
Departament of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
Interests: medicinal chemistry; Phytotherapy; medicinal plants; natural product; natural compound; antinociceptive activity; anticonvulsant activity

Special Issue Information

Dear Colleagues,

The discovery of drugs from medicinal plants highlights these species as an essential source of biologically active substances. Their metabolites perform diverse functions in plant physiology, but can also interact with various biological targets in other living organisms and result in changes in biological systems, such as inhibitory or stimulating actions on biochemical processes. These changes can cause pharmacological and/or toxic effects in animals and humans and have applicability in a pharmacotherapeutic approach. The volatile compounds found in plants have demonstrated several pharmacological activities, including anti-inflammatory and antinociceptive actions. These metabolites have also been used as prototypes and inspired the development of synthetic molecules with promising pharmacological activity. Thus, this chemical class represents a group of promising compounds in the search of new drugs to treat diseases associated with inflammatory processes and pain. Therefore, this Special Issue is an opportunity to debate the importance of volatile substances from plants in discovering anti-inflammatory and analgesic drugs and to discuss their mechanisms of action, including the phytochemical aspects of the isolated compounds.

Dr. Renan Oliveira Silva Damasceno
Dr. Damião Pergentino de Sousa
Guest Editors

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Keywords

  • volatile

  • essential oils
  • aromatic plants
  • aromas
  • anti-inflammatory
  • analgesic
  • phytochemistry
  • inhalation

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Published Papers (1 paper)

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Review

30 pages, 1994 KiB  
Review
Phytochemistry and Anti-Inflammatory and Antioxidant Activities of Cinnamomum osmophloeum and Its Bioactive Constituents: A Review
by Renan Oliveira Silva Damasceno, João Lucas Silva Pinheiro, Lorena Duarte da Silva, Lucas Henrique Marques Rodrigues, Jeremias Justo Emídio, Tamires Cardoso Lima and Damião Pergentino de Sousa
Plants 2025, 14(4), 562; https://doi.org/10.3390/plants14040562 - 12 Feb 2025
Cited by 1 | Viewed by 1175
Abstract
Cinnamomum osmophloeum, commonly known as indigenous cinnamon, is a tree species native to Taiwan’s hardwood forests. It has been extensively investigated for its chemical composition and bioactivities. Several reports have shown that C. osmophloeum leaves are rich in aromatic oils, which are [...] Read more.
Cinnamomum osmophloeum, commonly known as indigenous cinnamon, is a tree species native to Taiwan’s hardwood forests. It has been extensively investigated for its chemical composition and bioactivities. Several reports have shown that C. osmophloeum leaves are rich in aromatic oils, which are grouped into various chemotypes based on their major constituents. Components of the volatile oils included phenylpropanoids, monoterpenoids, sesquiterpenoids, phenols, coumarins, and other miscellaneous compounds. In addition, other secondary metabolites previously identified in this species included flavonol glycosides, phenolic acids, lignans, proanthocyanidins, and cyclopropanoids. C. osmophloeum is widely recognized for its medicinal and industrial applications, particularly its essential oils. In general, essential oils exhibit remarkable anti-inflammatory and antioxidant actions, enabling them to modulate key inflammatory mediators and neutralize free radicals. This review explored the phytochemical composition of the essential oils and extracts from C. osmophloeum as well as therapeutic potential of this species, focusing on the action mechanisms and clinical potential. We hope that this review will contribute to a better understanding of the biological effects of this plant and its potential applications in the management of conditions associated with inflammation and oxidative stress. Full article
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