Exploring the Immunomodulatory Potential of Plant Extracts

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 10 March 2026 | Viewed by 1628

Special Issue Editors


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Guest Editor
Institute of Physiology and Biochemistry ‘‘Ivan Djaja”, Faculty of Biology, University of Belgrade, Belgrade, Serbia
Interests: medicinal chemistry; physical organic chemistry; immunoinformatics
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Guest Editor
Institute of Physiology and Biochemistry “Ivan Đaja”, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia
Interests: immunology; immunomodulation; inflammation
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Guest Editor
Institute of Physiology and Biochemistry “Ivan Đaja”, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia
Interests: immunology; biochemistry; plant extracts

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Guest Editor
Institute of Botany and Botanical Garden “Jevremovac”, Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia
Interests: medicinal plants; plant extracts; phytochemistry; biological activities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Immunomodulation is a therapeutic intervention aimed at modifying the immune response either by enhancing or suppressing it, with the aim of regulating immune activity in order to achieve desired results in the treatment of various diseases and conditions. Although the health benefits of plant extracts are well known, present-day studies have come to focus more on investigating their immunomodulatory effects and modes of action. This Special Issue covers several topics, including the processes that underlie the immunomodulatory effects of plant extracts, how well they work to alter immune responses, and the possible uses of these compounds in the treatment of immunological disorders. It also seeks to explore the identification and characterization of the bioactive substances in different plant extracts that are responsible for their immunomodulatory properties. Furthermore, this Special Issue will emphasize the importance of understanding interactions between plant extracts and components of the immune system to enhance their therapeutic application. Through a comprehensive review of recent studies (review papers) and novel experimental findings (original articles), this Special Issue aims to provide valuable insights into the diverse range of plant extracts with immunomodulatory potential and their implications for human health and disease management.

Dr. Bojan Božić
Dr. Biljana Božić Nedeljković
Dr. Tanja Lunic
Dr. Mariana M. Oalđe Pavlović
Guest Editors

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Keywords

  • immunomodulation
  • plant extracts
  • immune mechanisms
  • health maintenance
  • immune homeostasis
  • disease prevention
  • modes of action
  • immune cells and molecules
  • therapeutic potential
  • immunological illnesses
  • bioactive substances
  • therapeutic applications

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Published Papers (1 paper)

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Research

16 pages, 1441 KiB  
Article
Echinacea purpurea and Onopordum acanthium Combined Extracts Cause Immunomodulatory Effects in Lipopolysaccharide-Challenged Rats
by Maria Vlasheva, Mariana Katsarova, Ilin Kandilarov, Hristina Zlatanova-Tenisheva, Petya Gardjeva, Petko Denev, Nora Sadakova, Viktor Filipov, Ilia Kostadinov and Stela Dimitrova
Plants 2024, 13(23), 3397; https://doi.org/10.3390/plants13233397 - 3 Dec 2024
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Abstract
Echinacea purpurea and Onopordum acanthium, which belong to the Asteraceae family, are widely used plants in traditional medicine. Their antioxidant, anti-inflammatory, antiviral, antibacterial, and antitumor effects are well known. However, there are no data on the effects of their combination. The aim of [...] Read more.
Echinacea purpurea and Onopordum acanthium, which belong to the Asteraceae family, are widely used plants in traditional medicine. Their antioxidant, anti-inflammatory, antiviral, antibacterial, and antitumor effects are well known. However, there are no data on the effects of their combination. The aim of the present study was to combine E. purpurea with O. acanthium to study the in vivo immunomodulatory effect of two combinations and to compare it with that of single plants. Their total polyphenolic and flavonoid content and the amounts of individual compounds characteristic of both species were determined. The influence of the obtained extracts on the serum concentrations of cytokines IFN-γ, TNF-α, and IL-10 in experimental animals with lipopolysaccharide-induced systemic inflammatory response was investigated. This research found that a combination of E. purpurea/O. acanthium in the ratio 1:1 reduced the proinflammatory cytokines TNF-α (244.82 pg/mL) and IFN-γ (1327.92 pg/mL) compared to the LPS-control, respectively, (574.17 pg/mL) and (3354.00 pg/mL), and the combination E. purpurea/O. acanthium in the ratio of 3:1 significantly increased the levels of the anti-inflammatory cytokine IL-10 (1313.95 pg/mL) compared to the LPS-control (760.09 pg/mL). In conclusion, our results could be a basis for future biomedical research on creating phytopreparations with an immunomodulatory effect. Full article
(This article belongs to the Special Issue Exploring the Immunomodulatory Potential of Plant Extracts)
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