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Special Issue "Biomedical and Biological Optical Device"

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A special issue of Photonics (ISSN 2304-6732).

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 7666

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Special Issue Editors

Prof. Dr. Giuseppe Quero

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Guest Editor

Optoelectronic Division—Engineering Department, University of Sannio, 82100 Benevento, Italy
Interests: object localization; motion detection; non-cooperative objects; reconfigurable wave chaos; wavefront shaping; microwaves; chaotic cavities; programmable metasurface; reconfigurable intelligent surface; sensing; wave-based analog computation; wireless communication; MIMO; reverberation chamber; compressed sensing; learned sensing; artificial intelligence; human-machine interaction

Dr. Patrizio Vaiano

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Guest Editor

Optoelectronic Division—Engineering Department, University of Sannio, 82100 Benevento, Italy
Interests: fiber optic; sensors; biosensors; lab on fiber; long period grating; dosimetry

Dr. Pablo Zubiate

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Guest Editor

Department of Electrical and Electronic Engineering, Public University of Navarra, 31006 Pamplona, Spain
Interests: optical sensor; LMRs probe; thin films; biosensing; nanostructures
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Special Issue Information

Dear Colleagues,

Biomedical optics is a highly interdisciplinary field where physicists, chemists, biologists, physicians and engineers work together to develop optical principle and tools to solve the problems appearing in biology and medicine. The focus of this issue is to provide an interdisciplinary forum for state-of-the-art developments in both fundamental and technological biophotonics device including the recent progress and trends in advanced biomedical imaging, sensing, spectroscopy, diagnostics, therapeutics, and instrumentation as well as in the modern field of nano-imaging and nano-sensing.

Dr. Quero Giuseppe
Dr. Patrizio Vaiano
Dr. Pablo Zubiate
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomedical and biological sensors
biophotonic sensing techniques

Published Papers (4 papers)

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Research

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15 pages, 3440 KiB

Open AccessArticle

Establishment of Personalized Finite Element Model of Crystalline Lens Based on Sweep-Source Optical Coherence Tomography

and

Photonics 2022, 9(11), 803; https://doi.org/10.3390/photonics9110803 - 26 Oct 2022

Viewed by 1106

Abstract

The virtual lens model has important value in ophthalmic research, clinical diagnosis, and treatment. However, the establishment of personalized lens models and the verification of accommodation accuracy have not been paid much attention. We proposed a personalized lens model establishment and the accommodation accuracy evaluation method based on sweep-source optical coherence tomography (SS-OCT). Firstly, SS-OCT is used to obtain a single lens image in the maximum accommodation state. After refraction correction, boundary detection, and curve fitting, the central curvature radius, thickness, and lens nucleus contour of the anterior and posterior surfaces of the lens were obtained. Secondly, a personalized finite element model improved from Burd’s model was established using these individual parameters, and the adaptation process of the lens model was simulated by pulling the suspensory ligament. Finally, the shape and refractive power changes of the real human lens under different accommodation stimuli were collected and compared with the accommodation process of the finite element model. The results show that the accommodation process of the finite element model is highly consistent with that of the real lens. From the un-accommodation state to the maximum-accommodation state, the difference rate of all geometric and refractive parameters between the two is less than 5%. Thus, the personalized lens finite element model obtained by the calibration and correction of the existing model can accurately simulate the regulation process of a specific human lens. This work helps to provide a valuable theoretical basis and research ideas for the study of clinical diagnosis and treatment of related diseases. Full article

(This article belongs to the Special Issue Biomedical and Biological Optical Device)

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14 pages, 9057 KiB

Open AccessArticle

Transient Thermal Response of Blood Vessels during Laser Irradiation Monitored by Laser Speckle Contrast Imaging

and

Photonics 2022, 9(8), 520; https://doi.org/10.3390/photonics9080520 - 26 Jul 2022

Cited by 1 | Viewed by 1323

Abstract

Real-time monitoring of blood flow and thrombosis formation induced by laser irradiation is critical to reveal the thermal-damage mechanism and successfully implement vascular-dermatology laser surgery. Laser speckle contrast imaging (LSCI) is a non-invasive technique to visualize perfusion in various tissues. However, the ability of the LSCI to monitor the transient thermal response of blood vessels, especially thrombus formation during laser irradiation, requires further research. In this paper, an LSCI system was constructed and a 632 nm He-Ne laser was employed to illuminate a Sprague Dawley rat dorsal skin chamber model irradiated by a 1064 nm Nd: YAG therapy laser. The anisotropic diffusion filtering (ADF) technique is implemented after temporal LSCI (tLSCI) processing to improve the SNR and temporal resolution. The speckle flow index is used to characterize the blood-flow velocity to reduce the computational cost. The combination of the tLSCI and ADF increases the temporal resolution by five times and the SNR by 17.2 times and 16.14 times, without and with laser therapy, respectively. The laser-induced thrombus formation and vascular damage during laser surgery can be visualized without any exogenous labels, which provides a powerful tool for thrombus monitoring during laser surgery. Full article

(This article belongs to the Special Issue Biomedical and Biological Optical Device)

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10 pages, 2431 KiB

Open AccessCommunication

Quantitative Analysis of Industrial Solid Waste Based on Terahertz Spectroscopy

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Photonics 2022, 9(3), 184; https://doi.org/10.3390/photonics9030184 - 14 Mar 2022

Cited by 4 | Viewed by 1660

Abstract

Industrial solid waste refers to the solid waste that is produced in industrial production activities. Without correct treatment and let-off, industrial solid waste may cause environmental pollution due to a variety of pollutants and toxic substances that are contained in it. Conventional detection methods for identifying harmful substances are high performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS), which are complicated, time-consuming, and highly demanding for the testing environment. Here, we propose a method for the quantitative analysis of harmful components in industrial solid waste by using terahertz (THz) spectroscopy combined with chemometrics. Pyrazinamide, benazepril, cefprozil, and bisphenol A are four usual hazardous components in industrial solid waste. By comparing with the Raman method, the THz method shows a much higher accuracy for their concentration analysis (90.3–99.8% vs. 11.7–86.9%). In addition, the quantitative analysis of mixtures was conducted, and the resulting prediction accuracy rate was above 95%. This work has high application value for the rapid, accurate, and low-cost detection of industrial solid waste. Full article

(This article belongs to the Special Issue Biomedical and Biological Optical Device)

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Review

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40 pages, 12918 KiB

Open AccessReview

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

Banshi D. Gupta

Anisha Pathak

and

Anand M. Shrivastav

Photonics 2022, 9(2), 86; https://doi.org/10.3390/photonics9020086 - 02 Feb 2022

Cited by 10 | Viewed by 2715

Abstract

Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic technology enables the interaction of light with functionalized fiber surfaces at remote locations to develop a novel, miniaturized and cost-effective lab on fiber technology for bio-sensing applications. The recent remarkable developments in the field of nanotechnology provide innumerable functionalization methodologies to develop selective bio-recognition elements for label free biosensors. These exceptional methods may be easily integrated with fiber surfaces to provide highly selective light-matter interaction depending on various transduction mechanisms. In the present review, an overview of optical fiber-based biosensors has been provided with focus on physical principles used, along with the functionalization protocols for the detection of various biological analytes to diagnose the disease. The design and performance of these biosensors in terms of operating range, selectivity, response time and limit of detection have been discussed. In the concluding remarks, the challenges associated with these biosensors and the improvement required to develop handheld devices to enable direct target detection have been highlighted. Full article

(This article belongs to the Special Issue Biomedical and Biological Optical Device)

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