Biomedical Photonics

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Biophotonics and Biomedical Optics".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 273

Special Issue Editor


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Guest Editor
School of Basic Medical Sciences, Fudan University, Shanghai 200433, China
Interests: biomedical photonics; photoacoustic imaging; optical microscopy; precision instrument; medical image analysis

Special Issue Information

Dear Colleagues,

The 21st century is regarded as the "Century of Brain Research." The brain, as the most important and complex organ in the human body, plays a crucial role in exploring mechanisms related to human thought, cognition, and behavior. Brain metabolism levels can measure the intensity of neural activity and energy consumption, making it essential in brain science research. Imaging technologies based on biomedical photonics offer non-invasive methods for studying brain metabolism and have had a profound impact on neuroscience and brain disease research. Among these imaging technologies, near-infrared imaging, Raman imaging, multiphoton microscopy, fluorescence wide-field microscopy, super-resolution fluorescence microscopy, and photoacoustic imaging have all been successfully applied to brain imaging, providing metabolism information about the brain at various scales and functions.

Currently, two-photon microscopy methods are capable of capturing brain neuron activity at high resolutions and fast speeds. On the other hand, photoacoustic imaging can acquire vascular multi-functional parameters in deep-brain tissue at a much higher temporal resolution. In this Research Topic, we welcome original research articles that utilize advanced optical imaging tools to study cerebral functional parameters like cerebral blood flow (CBF), oxygen saturation (sO2), cerebral metabolic rate of oxygen (CMRO2), as well as to study the neurovascular coupling effect and the brain metabolism process. Additionally, the call is also open for more theoretical approaches in the form of review, perspective, and opinion articles on promising future approaches for research on brain imaging, function, and metabolism.

In particular, we welcome contributions on the following subtopics:

  • Advanced biomedical photonics techniques, including but not limited to two-photon microscopy and imaging and photoacoustic imaging for assessing the cerebral functional parameters.
  • Exploiting multimodal imaging to provide etiologic insights into brain metabolism in vivo from molecular, structural, and functional perspectives.
  • Investigations into the molecular mechanisms of neurovascular coupling effects in the brain, revealed through in vivo optical imaging.
  • Review and perspective articles discussing the latest advances and future prospects of various optical imaging techniques for brain imaging, functionality, and metabolism.

Dr. Chao Liu
Guest Editor

Manuscript Submission Information

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Keywords

  • biomedical photonics
  • brain imaging and metabolism
  • two-photon microscopy
  • photoacoustic imaging

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Published Papers (1 paper)

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Research

12 pages, 1136 KiB  
Article
Hybrid Method for Solving the Radiative Transport Equation
by André Liemert, Dominik Reitzle and Alwin Kienle
Photonics 2025, 12(5), 409; https://doi.org/10.3390/photonics12050409 - 24 Apr 2025
Viewed by 157
Abstract
The spherical harmonics method (PN method) is often used for solving the radiative transport equation in terms of analytical functions. A severe and unsolved problem in this context was the evaluation of the angle-resolved radiance near sources and boundaries, which is [...] Read more.
The spherical harmonics method (PN method) is often used for solving the radiative transport equation in terms of analytical functions. A severe and unsolved problem in this context was the evaluation of the angle-resolved radiance near sources and boundaries, which is a serious limitation of this method in view of concrete applications, e.g., in biomedical optics for investigating the different types of optical microscopy, within NIR spectroscopy, such as for the determination of ingredients in foods or in pharmaceuticals, and within physics-based rendering. In this article, we report on a hybrid method that enables accurate evaluation of the angle-resolved radiance directly at the boundary of an anisotropically scattering medium, avoiding the problems of the traditional PN methods. The derived integral equation needed for the realization of the hybrid PN method is formally valid for an arbitrary convex bounded medium. The proposed approach can be evaluated with practically the same computational effort as the traditional PN method while being far more accurate. Full article
(This article belongs to the Special Issue Biomedical Photonics)
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