Membrane Transporters in Biomedicine and Drug Development
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 12179
Special Issue Editor
Interests: membrane transporters; ABC transporters; multidrug resistance; stem cell membrane transporters; drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of Pharmaceutics aims to cover the field of cellular membrane transporters in biomedical research, especially focusing on targeted and accidental drug effects, as well as the role of membrane transporters in the development of new pharmaceutical agents. While earlier concepts of drug permeation through tissue barriers emphasized the role of lipid solubility, by now it has become generally accepted that the transmembrane movement of most of the xenobiotics and pharmaceutical agents depends on the function of membrane transporters. Thus, in addition to drug-metabolizing enzymes, the in vivo ADME-tox parameters are crucially affected by the transporter-dependent entry or efflux of the clinically applied compounds. By a specific or non-specific modulation of these transporters may elicit, in some cases unexpected major effects on tissue-dependent efficacy and toxicity. New in vitro and in vivo techniques have been developed to study these phenomena, and regulatory agencies strongly emphasize the need for preclinical studies of transporters potentially involved in drug interactions. This Special Issue should help to provide a collection of original research and review papers covering this biomedically important field, further helping the advancement of clinical applications.
Prof. Dr. Sarkadi Balázs
Guest Editor
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Keywords
- membrane transporters
- transporter-drug interactions
- regulation of transporter function
- regulation of transporter expression
- transporters in drug development
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