Ubiquitous Heterocycles in Medicinal Chemistry and Pharmaceutical Industry

Dear Colleagues,

Incorporation of heterocyclic groups into compounds can serve as a linker to generate favorable geometric conformations or generate binding interactions with a biological target. Heterocycles are also used as functional group replacements (bioisosteres) for carboxylates, esters, carbamates, nitriles, etc. to optimize drug-likeness of the molecules. The presence of oxygen, sulphur and nitrogen atoms often polarizes the ring system and has been used to optimize physical properties including solubility or crystal morphology. In view of the predominance of heterocyclic groups, an updated and detailed account of the pharmacological properties of some ubiquitous heterocycles in medicinal chemistry and pharmaceutical industry will be described in this Special Issue. Besides, some outlooks on current issues and future directions in this field of research will also be provided.

Prof. Dr. Peng Zhan
Prof. Dr. Shuang-Xi Gu
Prof. Dr. Edeildo Ferreira da Silva-Júnior
Guest Editors

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