The Role of Fungi in Pharmaceutical Biotechnology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 6732

Special Issue Editors


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Guest Editor
Department of Microbiology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
Interests: microbiology (bacteria, viruses, fungi, parasites); microbiology and laboratory in public health; antibiotics (all linked with this matter); immunology; surveillance; epidemiology; drug discovery; drug design; medicinal chemistry; bacteriophages; biofilms
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Guest Editor
VTT Technical Research Centre of Finland, FI-02044 Espoo, Finland
Interests: enzymes; pharmaceutical proteins; precision fermentation; cell free protein expression; fungal expressions; raman spectroscopy

Special Issue Information

Dear Colleagues,

Biopharmaceuticals are an important and continuously growing class of pharmaceuticals, having found frequent use and an integral role in the treatment of many different diseases. In general, the development and production of biopharmaceuticals involves prokaryote systems; however, most often, due to the need of complex (post-translational) modifications, eukaryotic systems such a yeast or mammalian cells are used. In addition to filamentous fungi-derived pharmaceuticals, molds and fungi still play an important role in antibiotic production. More recently, fungi have been showing the highest titers for protein and peptide production, including biopharmaceuticals.

The aim of this Special Issue of Pharmaceutics is to collect research and review papers regarding products manufactured in, extracted from, or semisynthesized with the aid of fungi. We welcome articles dealing with all aspects of fungal-based biotechnology and invite researchers and drug developers to publish their original research or review articles with expert opinions and perspectives in the area of therapeutics.

Prof. Dr. Mircea Ioan Popa
Dr. Marco Casteleijn
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungi
  • biopharmaceuticals
  • biotechnology
  • proteins and peptides
  • nucleic acids

Published Papers (1 paper)

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Review

71 pages, 4462 KiB  
Review
How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances
by Andreas Schüller, Lena Studt-Reinhold and Joseph Strauss
Pharmaceutics 2022, 14(9), 1837; https://doi.org/10.3390/pharmaceutics14091837 - 31 Aug 2022
Cited by 10 | Viewed by 3491
Abstract
Fungal species have the capability of producing an overwhelming diversity of bioactive substances that can have beneficial but also detrimental effects on human health. These so-called secondary metabolites naturally serve as antimicrobial “weapon systems”, signaling molecules or developmental effectors for fungi and hence [...] Read more.
Fungal species have the capability of producing an overwhelming diversity of bioactive substances that can have beneficial but also detrimental effects on human health. These so-called secondary metabolites naturally serve as antimicrobial “weapon systems”, signaling molecules or developmental effectors for fungi and hence are produced only under very specific environmental conditions or stages in their life cycle. However, as these complex conditions are difficult or even impossible to mimic in laboratory settings, only a small fraction of the true chemical diversity of fungi is known so far. This also implies that a large space for potentially new pharmaceuticals remains unexplored. We here present an overview on current developments in advanced methods that can be used to explore this chemical space. We focus on genetic and genomic methods, how to detect genes that harbor the blueprints for the production of these compounds (i.e., biosynthetic gene clusters, BGCs), and ways to activate these silent chromosomal regions. We provide an in-depth view of the chromatin-level regulation of BGCs and of the potential to use the CRISPR/Cas technology as an activation tool. Full article
(This article belongs to the Special Issue The Role of Fungi in Pharmaceutical Biotechnology)
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