Innovations in Controlled Release Systems of Marine- and Plant/Herbal-Derived Bioactives for Pharmaceuticals and Nutraceuticals

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 1257

Special Issue Editors


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Guest Editor
Laboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechneiou St. Zografou Campus, 15780 Athens, Greece
Interests: process design; food engineering; unit operations; product development; drying; encapsulation; extraction
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechneiou St. Zografou Campus, 15780 Athens, Greece
Interests: chemical engineering; encapsulation; electrospinning; extraction; smart packaging

E-Mail Website
Guest Editor
Laboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechneiou St. Zografou Campus, 15780 Athens, Greece
Interests: process optimization; functional ingredients; circular economy; sustainability; extraction process; encapsulation process

Special Issue Information

Dear Colleagues,

The Special Issue entitled "Innovations in Controlled Release Systems of Marine- and Plant/Herbal-Derived Bioactives for Pharmaceuticals and Nutraceuticals" will explore recent advances in the development and application of controlled release systems for bioactive compounds sourced from marine and plant/herbal origins. Because of their various pharmacological properties and natural origins, these bioactives have great potential in medicinal and health-promoting uses. However, issues such as stability, bioavailability, and targeted delivery must be addressed before they may completely fulfill their potential in pharmaceutical and nutraceutical applications. This Special Issue will cover cutting-edge research and creative approaches that improve the delivery efficiency, stability, and bioavailability of these substances using controlled release technologies. We welcome submissions that look at novel encapsulation techniques, biocompatible materials, release kinetics, and the function of controlled release in improving therapeutic efficacy and safety.

Prof. Dr. Magda Krokida
Dr. Marina Stramarkou
Dr. Sofia Papadaki
Guest Editors

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Keywords

  • bioactive compound
  • bioavailability
  • controlled release system

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Published Papers (1 paper)

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Research

18 pages, 4166 KiB  
Article
GinExtraMed: Focus on Rosa canina L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing
by Martina Rossi, Simone Rossello, Valentina Sallustio, Manuela Mandrone, Teresa Cerchiara, Ilaria Chiocchio, Giuseppe Chidichimo, Michele Protti, Laura Mercolini, Barbara Luppi, Federica Bigucci, Angela Abruzzo and Concettina Cappadone
Pharmaceutics 2025, 17(5), 632; https://doi.org/10.3390/pharmaceutics17050632 - 9 May 2025
Viewed by 585
Abstract
Background/Objectives: Over the last decade, the development of innovative wound products has continued to be a focus of intense research to meet the huge demand of patients. The aim of this work was to develop novel medicated Spanish broom wound dressings capable of [...] Read more.
Background/Objectives: Over the last decade, the development of innovative wound products has continued to be a focus of intense research to meet the huge demand of patients. The aim of this work was to develop novel medicated Spanish broom wound dressings capable of releasing Rosa canina extract, recognized for its high antioxidant activity. Methods:Rosa canina extract was encapsulated in two different nanocarriers, namely glycethosomes and allanthosomes. The physico-chemical and functional characteristics of the obtained vesicles were described, including their size, particle size distribution, ζ potential, and encapsulation efficiency (EE). In addition, vesicles cytotoxicity and cell proliferation were evaluated on human fibroblasts. Furthermore, loaded vesicles were sunk into Spanish broom dressings, analyzed by confocal microscopy, and, finally, evaluated for their wound healing ability by scratch test. Results: Both carriers are nanometric in size, with a good EE (>70%), and a negative ζ potential. Additionally, vesicles are biosafe, non-cytotoxic, and lead to complete closure of the scratch in about 30 h. Conclusions: The findings showed that the developed Spanish broom dressings have the potential to be an efficient and innovative wound care product for accelerating skin wounds. Full article
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