Advancements and Innovations in Antibody Drug Conjugates, 2nd Edition
A Special Issue of Pharmaceutics (ISSN 1999-4923) belonging to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1376
Editors
Interests: medicinal chemistry; antibody drug conjugates; fluorescence imaging; targeted drug delivery; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals
Interests: biomaterials; nanobiotechnology; tissue engineering; drug delivery; nanomedicine; translational medicine; gene delivery; interdisciplinary methodologies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibody–drug conjugates (ADCs) represent a groundbreaking advancement in targeted cancer therapy, merging the specificity of monoclonal antibodies with a highly potent cytotoxic small-molecule drug. ADCs aim to improve efficacy by reducing side effects through the specific targeting of cancer cells while sparing healthy tissues. Recent innovations in ADC development have focused on optimizing antibody engineering, bispecific antibodies, combination therapies, linker stability, and the choice of payloads to enhance the therapeutic index. Improved conjugation techniques, payload delivery mechanisms, and linker chemistries are advancing the field towards greater efficacy and safety profiles.
This Special Issue highlights the latest advancements and innovations in ADC technology, including recent antibody-based drug delivery systems, approved ADCs, clinical development, cytotoxic payload, drug linker design, cleavable linker design, site-specific conjugation, biodistribution, pharmacokinetics, and molecular imaging.
We look forward to receiving your contributions.
Dr. Ebaston Thankarajan
Prof. Dr. Wei-En Yuan
Guest Editors
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Keywords
- antibody–drug conjugates
- monoclonal antibodies
- targeted therapies
- linker technologies
- site-specific conjugation
- bioimaging
- pharmacokinetics
- therapeutic index
- next-generation ADCs
- drug resistance
- bispecific antibodies
- combination therapies
- off-target toxicity
- efficacy and safety
- tumor-specific antigens
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