Biomaterials and Drug Delivery Systems for Tissue Engineering and Regenerative Medicine
A Special Issue of Pharmaceutics (ISSN 1999-4923) belonging to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 25 May 2027 | Viewed by 65
Editors
Interests: biomaterials; bone tissue engineering; thin films and coatings
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; tissue engineering; surface modification of medical devices
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tissue engineering (TE) combines principles of engineering, medicine, and biology to create novel tissues with functions similar to those of natural ones, enabling them to replace, repair, or enhance tissue and organ function, which has led to the emergence of a new branch of medicine—regenerative medicine. TE strategies include both in vitro and in vivo approaches that utilize biomaterials, cells from various sources, and bioactive molecules. Biomaterials play a crucial role in almost all TE strategies. Although they have been used for centuries in certain biomedical applications, recent scientific advances have greatly expanded their potential for use in clinical practice. In addition to inherent biocompatibility, appropriate mechanical properties, bioactivity, and biodegradability, today's research focuses on developing biomaterials that integrate with surrounding tissue and exhibit bioinductive properties, thereby enhancing the regenerative capacity of damaged tissues and providing support for cell growth.
This Special Issue welcomes studies presenting novel approaches and recent advances in the application of various biomaterials across all areas of tissue engineering and regenerative medicine, including systems for targeted drug delivery within the human body.
Potential topics include, but are not limited to, the following areas:
- Various methods of biomaterials fabrication.
- Scaffolds for tissue and organ regeneration.
- Stem cells, bioactive molecules and growth factors.
- Surface modification of medical implants.
- Systems for targeted delivery and/or controlled release of drugs and other bioactive molecules.
- Tissue-specific applications (bone, cartilage, skin, dental, neural, etc.).
- In vitro and in vivo evaluation of biomaterials and drug delivery systems.
- Advanced biphasic and multi-layered scaffolds: Engineering constructs that can simultaneously regrow two different tissue types (such as subchondral bone and articular cartilage) using distinct spatial gradients.
- Acellular regenerative matrices: Biomaterials designed to recruit native host stem cells or progenitor cells directly from surrounding vascular beds, eliminating the need for expensive external cell-culturing.
- Polysaccharide and nanofibrillar hydrogels: The mechanical reinforcement of soft hydrogels (like hyaluronic acid or collagen) using rigid nanostructures (like cellulose nanofibrils) to withstand joint loading.
- Controlled and controlled drug delivery: Systems that embed slow-release growth factors, anti-inflammatory drugs, or anti-aging targets (such as inhibitors of the 15-PGDH aging protein) directly into a healing matrix.
- Biocompatibility and translational animal models: In vitro non-cytotoxicity evaluations and in vivo large-animal functional studies mapping the degradation speed of materials against native tissue regrowth.
Dr. Božana Petrović
Prof. Dr. Vukoman Jokanovic
Guest Editors
Manuscript Submission Information
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Keywords
- biomaterials
- tissue engineering
- nanotechnology
- regenerative medicine
- drug delivery
- controlled drug release
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