Biomaterials and Agents: Pharmaceutical and Biomedical Applications in Dental and Orthopedic Research

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 490

Special Issue Editors


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Guest Editor
Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11351 Belgrade, Serbia
Interests: biomaterials; bone tissue engineering; dental materials; bioactive coatings
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E-Mail Website
Guest Editor
Vinca Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11351 Belgrade, Serbia
Interests: material characterization; materials; nanomaterials; material; X-ray diffraction; thin films and nanotechnology; mechanical properties

Special Issue Information

Dear Colleagues,

Biomaterials play a crucial role in restorative dentistry and orthopedics, with a wide range of applications, including use in dental and orthopedic implants and scaffolds for bone and cartilage tissue regeneration. When enriched with different biological agents, they can be used in medical treatments to deliver antibiotics, anti-inflammatory drugs, or agents that promote healing and tissue regeneration.

This Special Issue will focus on pharmaceutical and biomedical applications of biomaterials and agents in dentistry and orthopedics, with a strong emphasis on new technologies, innovations, and advancements in material production and applied treatments. Potential topics include, but are not limited to, the following:

  1. Biological Agents for Dental and Orthopedic Applications: The use of biological agents for dental pulp regeneration and the repair of dental tissues; applications of biological agents in bone repair and regeneration, including osteoconductive and osteoinductive properties; the use of biological agents for promoting cartilage regeneration and repair.
  2. Nanomaterials and Nanocomposites in Dentistry and Orthopedics: The development and application of nanomaterials for drug delivery in dental and orthopedic treatments; the use of nanocomposites to enhance the performance of dental and orthopedic implants; nanotechnology-based approaches to infection prevention in orthopedic and dental surgeries.
  3. Advanced Biomaterials in Regenerative Medicine: Synthetic and natural biomaterials for bone and cartilage regeneration; composite biomaterials (ceramics, polymers, hydrogels) for optimal tissue repair and regeneration.
  4. Cell–Biomaterial Interactions: Study of cell–biomaterial interactions in dental and orthopedic applications; mechanisms behind biological agents promoting cell adhesion, proliferation, and differentiation on biomaterial surfaces.
  5. 3D Printing and Bioprinting Technologies: Applications of 3D printing to create dental and orthopedic prostheses; the development of bioprinted scaffolds for tissue engineering applications.
  6. Drug Delivery Applications: Exploration of biomaterials as platforms for targeted drug delivery in dental and orthopedic treatments, including the development of smart drug delivery systems that can release therapeutic agents in response to specific stimuli (e.g., pH, temperature, or enzyme activity); the use of nanomaterials and microencapsulation technologies to enhance the stability, bioavailability, and controlled release of drugs; the integration of 3D printing technologies to create personalized drug delivery devices and scaffolds that can release therapeutic agents locally.

We welcome contributions that address these and related topics. Through this Special Issue, we aim to advance the understanding and application of biomaterials and agents in dental and orthopedic research.

Dr. Božana Petrović
Prof. Dr. Vukoman R. Jokanović
Guest Editors

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Keywords

  • biomaterials
  • dental and orthopedic applications
  • regenerative medicine
  • nanotechnology
  • 3D printing
  • drug delivery systems

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Published Papers (1 paper)

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Research

21 pages, 14021 KiB  
Article
Three-Dimensional-Printed Bone Grafts for Simultaneous Bone and Cartilage Regeneration: A Promising Approach to Osteochondral Tissue Engineering
by Smiljana Paraš, Božana Petrović, Dijana Mitić, Miloš Lazarević, Marijana Popović Bajić, Marija Živković, Milutin Mićić, Vladimir Biočanin, Slavoljub Živković and Vukoman Jokanović
Pharmaceutics 2025, 17(4), 489; https://doi.org/10.3390/pharmaceutics17040489 - 8 Apr 2025
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Abstract
Background/Objectives: A novel 3D-printed, bioresorbable bone graft, made of nanohydroxyapatite (nHAP) covered by poly(lactide-co-glycolide) (PLGA), showed strongly expressed osteoinductive properties in our previous investigations. The current study examines its application in the dual regeneration of bone and cartilage by combining with nHAP [...] Read more.
Background/Objectives: A novel 3D-printed, bioresorbable bone graft, made of nanohydroxyapatite (nHAP) covered by poly(lactide-co-glycolide) (PLGA), showed strongly expressed osteoinductive properties in our previous investigations. The current study examines its application in the dual regeneration of bone and cartilage by combining with nHAP gel obtained by nHAP enrichment with hydroxyethyl cellulose, sodium hyaluronate, and chondroitin sulfate. Methods: In the in vitro part of the study, the mitochondrial activity and osteogenic and chondrogenic differentiation of stem cells derived from apical papilla (SCAPs) in the presence of nHAP gel were investigated. For the in vivo part of the study, three rabbits underwent segmental osteotomies of the lateral condyle of the femur, and defects were filled by 3D-printed grafts customized to the defect geometry. Results: In vitro study revealed that nHAP gel displayed significant biocompatibility, substantially increasing mitochondrial activity and facilitating the osteogenic and chondrogenic differentiation of SCAPs. For the in vivo part of the study, after a 12-week healing period, partial resorption of the graft was observed, and lamellar bone tissue with Haversian systems was detected. Histological and stereological evaluations of the implanted grafts indicated successful bone regeneration, marked by the infiltration of new bone and cartilaginous tissue into the graft. The existence of osteocytes and increased vascularization indicated active osteogenesis. The hyaline cartilage near the graft showed numerous new chondrocytes and a significant layer of newly formed cartilage. Conclusions: This study demonstrated that tailored 3D-printed bone grafts could efficiently promote the healing of substantial bone defects and the formation of new cartilage without requiring supplementary biological factors, offering a feasible alternative for clinical bone repair applications. Full article
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