Recent Advances in Controlled Release and Targeted Drug Delivery Formulations for Improved Efficacy and Reduced Side Effects

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 March 2027 | Viewed by 1336

Editor


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Guest Editor
Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Republic of Korea
Interests: pharmaceutical formulation; controlled release; preformulation; poorly water-soluble drug; local drug delivery

Special Issue Information

Dear Colleagues,

Over the past few decades, significant progress has been achieved in the controlled release and targeted delivery of a wide range of drugs, advances which have greatly improved therapeutic efficacy while reducing adverse effects. Despite these ongoing efforts, important challenges remain in developing new and more effective pharmaceutical dosage forms and in demonstrating their performance.

In this Special Issue, we focus on novel delivery systems that enable effective targeting and site-specific drug release. We welcome original research articles covering the design, manufacturing, characterization, and in vitro and in vivo evaluation of new pharmaceutical formulations, and review articles are also welcome. Your contributions and scientific findings will inspire researchers and professionals in both academia and the pharmaceutical industry. We look forward to receiving your submissions.

Dr. Dongjin Jang
Guest Editor

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Keywords

  • pharmaceutical formulation
  • controlled release
  • drug targeting
  • improved efficacy
  • local drug delivery
  • reduced side effect

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Published Papers (1 paper)

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Research

22 pages, 3617 KB  
Article
Amorphous Solid Dispersion Hydrogel Platform for Transdermal Delivery of Cannabidiol with Therapeutic Potential for Dermatitis
by Badmaarag-Altai Chuluunbaatar, Yujin Jeong, Jieun Ok, Yujin Song, Jae Woon Son, Ji-Hyun Kang, Wonwoong Lee and Kyung Hyun Min
Pharmaceutics 2026, 18(6), 666; https://doi.org/10.3390/pharmaceutics18060666 - 28 May 2026
Cited by 1 | Viewed by 918
Abstract
Background/Objectives: Cannabis sativa is the source of cannabidiol (CBD), a non-intoxicating phytocannabinoid with analgesic and anti-inflammatory qualities that has demonstrated therapeutic potential in inflammatory skin conditions like dermatitis. However, low bioavailability and poor water solubility restrict its topical application. This study attempted [...] Read more.
Background/Objectives: Cannabis sativa is the source of cannabidiol (CBD), a non-intoxicating phytocannabinoid with analgesic and anti-inflammatory qualities that has demonstrated therapeutic potential in inflammatory skin conditions like dermatitis. However, low bioavailability and poor water solubility restrict its topical application. This study attempted to improve CBD solubility and transdermal delivery using an amorphous solid dispersion (ASD)-based hydrogel system. Methods: CBD was stabilized in its amorphous form using an ASD strategy and incorporated into a hydrogel matrix. The CBD-ASD hydrogel was characterized by particle size analysis, scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), rheological assessment, swelling studies, and diffusion experiments using Franz cells. Biological evaluations included cytotoxicity testing in human dermal fibroblast (HDF) cells, wound-healing assays, RT-qPCR-based anti-inflammatory analysis, antioxidant activity (DPPH assay), and antibacterial testing against Staphylococcus aureus. Results: Physicochemical analyses confirmed successful amorphous dispersion of CBD within a stable hydrogel network. The formulation exhibited sustained drug release over 144 h, achieving 86.32% cumulative release with diffusion-controlled kinetics. Rheological and swelling properties demonstrated mechanical stability and hydration suitability for long-term topical application, while Franz diffusion studies confirmed effective transdermal permeation. The CBD-ASD hydrogel showed no cytotoxicity in HDF cells and significantly enhanced wound closure. It also downregulated pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Additionally, the formulation demonstrated 65.63 ± 10.00% DPPH radical scavenging activity and over 99% antibacterial inhibition. Conclusions: The CBD-ASD hydrogel represents a stable, multifunctional delivery platform that overcomes CBD solubility limitations and enhances therapeutic efficacy for inflammatory skin diseases. Full article
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