Advances in Pharmacokinetics and Drug-Drug Interactions

Dear Colleagues,

Pharmacokinetics is a discipline that explains the absorption, distribution, metabolism, and excretion (ADME) of drugs over time, with the goal of understanding how our body responds to drugs. The ADME of the drug could be affected by concurrently administered drugs called drug-drug interaction (DDI). Such drug interactions can increase or decrease the systemic exposure of the drug and even lead to unexpected side effects of the drug. Therefore, understanding of DDI potential is critical not only for successful drug development but also for the safe and effective use of a drug in clinical practice. Due to this reason, regulatory agencies require pharmaceutical developers to evaluate DDI potential according to their guidelines. Multiple approaches, including in vitro, in vivo, and in silico methods, have been applied to assess DDI potential throughout the drug discovery and development processes. The impact of DDI on PK/PD of a compound can also be evaluated in clinical trials, if necessary.

In this special issue, we would like to cover manuscripts that describe basic, applied, and in vitro-in vivo experimental results, as well as in silico modeling and simulation approach to highlight recent advances in DMPK and clinical pharmacology for DDI evaluation and prediction. We welcome the submission of original and review articles on DDI.

Dr. Keumhan Noh
Dr. Jong-Hwa Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.