Special Issue "Selected papers from 7th APS International PharmSci Conference"

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (31 March 2017)

Special Issue Editors

Guest Editor
Prof. Dr. Yvonne Perrie

Chair in Drug Delivery, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
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Interests: liposomes; gene therapy; vaccines; colloidal systems; pharmaceutics; pharmaceutical education; drug delivery
Guest Editor
Dr. Carol O'Connor

Scientific Administrator, The Academy of Pharmaceutical Sciences, Leicester, LE4 9HA, UK
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Interests: pharmaceutics; pharmaceutical education; inhalation drug delivery; drug development; pharmaceutical industry; project management

Special Issue Information

Dear Colleague,

The 7th APS International PharmSci Conference (http://www.ukpharmsci.org/whyattend_2016.asp), will be held at the Technology and Innovation Centre, University of Strathclyde, Glasgow, UK, from 5–7 September 2016.

The Conference is the leading UK Pharmaceutical Science conference, and has firmly established itself as the premier pharmaceutical science event in the UK. This Special Issue is dedicated as a memorial proceeding of the conference, and to provide a platform for academic and industrial institutions scientists, so as to seek and exchange updated and new knowledge on pharmaceutical science.

Participants of the conference will enjoy a 50% discount on the APC (article processing charges). We cordially invite you to contribute original research papers, reviews or communications to this Special Edition of Pharmaceutics.

Prof. Dr. Yvonne Perrie
Dr. Carol O’Connor
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biopharmaceutics
  • Drug Metabolism
  • Pharmaceutical and biochemical analysis
  • Drug Delivery
  • Formulation
  • Pharmacology and Clinical Research
  • Pharmaceutical Technology
  • Pharmaceutical Microbiology

Published Papers (2 papers)

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Research

Open AccessArticle An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It
Pharmaceutics 2017, 9(2), 20; https://doi.org/10.3390/pharmaceutics9020020
Received: 16 March 2017 / Revised: 15 May 2017 / Accepted: 24 May 2017 / Published: 2 June 2017
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Abstract
The aim of this study is to evaluate the adhesion ability of okra gum, which is gaining popularity as a tablet binder. For this purpose, gum was extracted from okra pods, and the binding strength of different concentrations (1%, 3%, and 5%) was
[...] Read more.
The aim of this study is to evaluate the adhesion ability of okra gum, which is gaining popularity as a tablet binder. For this purpose, gum was extracted from okra pods, and the binding strength of different concentrations (1%, 3%, and 5%) was determined quantitatively. Additionally, naproxen sodium tablets were prepared by using okra gum as a binder and were evaluated for their properties including hardness, friability, disintegration time, and dissolution rate. The binding strength values were compared with that of pre-gelatinized starch, a commonly used tablet binder. The results from universal testing machine indicate that the binding strengths of all dispersions of okra increase as the concentration increases from 1% to 5% and ranges from 2.5 to 4.5 N, which are almost twice a high as those of pre-gelatinized starch. The tablets prepared with okra gum have shown good mechanical strength with hardness values of 7–8.5 kg/cm2 and a friability <1%, comparable to tablets prepared with starch. The disintegration time was longer (7.50 min with okra gum and 5.05 min with starch paste), and the drug release from these tablets was slower than the formulations with starch. The higher binding ability of okra gum probably linked with its chemical composition as it mainly contains galactose, rhamnose, and galacturonic acid. This study concludes that okra gum is a better binder than pre-gelatinized starch, it might be explored in future for introduction as a cost-effective binder in the pharmaceutical industry. Full article
(This article belongs to the Special Issue Selected papers from 7th APS International PharmSci Conference)
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Graphical abstract

Open AccessArticle Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation
Pharmaceutics 2017, 9(2), 16; https://doi.org/10.3390/pharmaceutics9020016
Received: 6 March 2017 / Revised: 4 May 2017 / Accepted: 10 May 2017 / Published: 16 May 2017
Cited by 1 | PDF Full-text (1540 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by
[...] Read more.
High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules. Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2.5 GPa. No phase transition was observed up to this pressure. A reconstructive phase transition is required to induce conformational changes in the structure, which was confirmed by the results of crystallisation at high pressure. Full article
(This article belongs to the Special Issue Selected papers from 7th APS International PharmSci Conference)
Figures

Graphical abstract

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