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Pharmaceutics 2017, 9(2), 16;

Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation

College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, UK
Author to whom correspondence should be addressed.
Academic Editor: Arvind Bansal
Received: 6 March 2017 / Revised: 4 May 2017 / Accepted: 10 May 2017 / Published: 16 May 2017
(This article belongs to the Special Issue Selected papers from 7th APS International PharmSci Conference)
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High-pressure crystallisation has been successfully used as an alternative technique to prepare Form II of a non-steroidal anti-inflammatory drug, mefenamic acid (MA). A single crystal of Form II, denoted as high-pressure Form II, was grown at 0.3 GPa from an ethanolic solution by using a diamond anvil cell. A comparison of the crystal structures shows that the efficient packing of molecules in Form II was enabled by the structural flexibility of MA molecules. Compression studies performed on a single crystal of Form I resulted in a 14% decrease of unit cell volume up to 2.5 GPa. No phase transition was observed up to this pressure. A reconstructive phase transition is required to induce conformational changes in the structure, which was confirmed by the results of crystallisation at high pressure. View Full-Text
Keywords: mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallisation; non-steroidal anti-inflammatory drugs mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallisation; non-steroidal anti-inflammatory drugs

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Abbas, N.; Oswald, I.D.H.; Pulham, C.R. Accessing Mefenamic Acid Form II through High-Pressure Recrystallisation. Pharmaceutics 2017, 9, 16.

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