Biomaterials: Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 637

Special Issue Editor


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Guest Editor
1. Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Haya de la Torre and Medina Allende, Science Building 2, Cordoba X5000HUA, Argentina
2. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica, CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas, UNITEFA, Cordoba X5000HUA, Argentina
Interests: pharmaceutics; drug development; drug delivery systems; ligand–receptor interactions; nanoparticles; solid-state characterization; biodegradation; physical and chemical stability
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Special Issue Information

Dear Colleagues,

Biomaterials are natural or synthetic functional materials with intrinsic properties and remarkable versatility. In particular, their exceptional biocompatibility and biofunctions enable a wide range of applications, including supporting, enhancing, restoring, or replacing the biological functions of damaged tissues while remaining in continuous contact with body fluids. These materials offer advanced technological possibilities for innovation applied in pharmaceutical science, redefining the standards of pharmacotherapy and scientific research, with one of the most important applications being the design of controlled drug delivery systems. Other applications include tissue repair, organ regeneration, diagnostic tools, and vaccine development. Their biocompatibility is essential for ensuring their interaction with biological systems without producing adverse reactions or toxicity. Biomaterials can be used in drug delivery systems for injection, either orally or in the eye, lungs, nose, and dermis.

This Special Issue aims to elucidate the latest advances in these innovative materials, their benefits, future directions, and expanded applications, highlighting their critical relevance in the design of effective drug delivery systems to improve patient treatment across a diverse range of diseases.

Dr. Claudia Garnero
Guest Editor

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Keywords

  • natural biomaterials
  • synthetic biomaterials
  • drug delivery systems
  • tissue engineering
  • disease diagnosis
  • wound healing

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Published Papers (1 paper)

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Review

27 pages, 2654 KiB  
Review
Bioactive Compound-Fortified Nanomedicine in the Modulation of Reactive Oxygen Species and Enhancement of the Wound Healing Process: A Review
by Popat Mohite, Abhijeet Puri, Shubham Munde, Nitin Ade, Aarati Budar, Anil Kumar Singh, Deepanjan Datta, Supachoke Mangmool, Sudarshan Singh and Chuda Chittasupho
Pharmaceutics 2025, 17(7), 855; https://doi.org/10.3390/pharmaceutics17070855 - 30 Jun 2025
Viewed by 510
Abstract
Wound healing is a complex biological process that involves the regulation of reactive oxygen species (ROS), which play a critical role in cellular signaling and tissue repair. While the dual nature of ROS means that maintaining controlled levels is essential for effective wound [...] Read more.
Wound healing is a complex biological process that involves the regulation of reactive oxygen species (ROS), which play a critical role in cellular signaling and tissue repair. While the dual nature of ROS means that maintaining controlled levels is essential for effective wound healing, excessive ROS production can hinder the recovery process. Bioactive compounds represent promising therapeutic candidates enriched with polyphenols, which are known for their high therapeutic properties and minimal adverse effects, and are thus highlighted as promising therapeutic candidates for wound healing due to their antioxidant properties. However, their clinical application is often limited due to challenges such as poor solubility and low bioavailability. To overcome this, the encapsulation of these compounds into nanocarriers has been proposed, which enhances their stability, facilitates targeted delivery, and allows for controlled release. The present review highlights emerging innovations in nanomedicine-based drug delivery of natural antioxidants for precise modulation of ROS in wound healing. Moreover, the review elaborates briefly on various in vitro and in vivo studies that assessed the ROS levels using different fluorescent dyes. By modulating ROS levels and improving the local microenvironment at wound sites, these bioactive-nanomedicine formulations can significantly accelerate the healing process of wounds. The review concludes by advocating for further research into optimizing these nano-formulations to maximize their potential in clinical settings, thereby improving therapeutic strategies for wound care and regeneration. Full article
(This article belongs to the Special Issue Biomaterials: Pharmaceutical Applications)
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