Anti-Inflammatory Effects from Natural Bioactive Compounds—from Bench to Bedside, 3rd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 559
Special Issue Editor
Interests: biopharmaceutics; inflammation; morphophysiology; drug design; natural products; antioxidants; gastrointestinal diseases; diabetes; wound healing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation is a response of organisms to the breakdown of tissue homeostasis. Infection, injury, autoimmune diseases, and chemicals can cause inflammation. The acute inflammatory response begins with increased vascular permeability and leukocyte migration, which will try to eliminate pathogenic organisms through the release of reactive oxygen species, reactive nitrogen species, and proteases. Additionally, neutrophils release inflammatory mediators, including chemokines, attracting macrophages to the site of inflammation and increasing the inflammatory response. These macrophages produce a whole cascade of inflammatory mediators, such as prostaglandins, leukotrienes, and cytokines. The chronic inflammatory response starts with the persistence of the inflammatory agent in a process that could be harmful not only to the inflammatory agent, but also to healthy tissues.
Although conventional anti-inflammatory treatments demonstrate effectiveness in treating inflammation, their use could trigger low, mild, and severe adverse effects. The use of biopharmaceutics and natural products of animal or vegetal origin to treat inflammation is increasing worldwide and encouraging researchers to investigate the anti-inflammatory mechanisms of isolated compounds from natural sources.
Thus, this Special Issue will highlight current research exploring the anti-inflammatory mechanisms of bioproducts of natural origin (including but not limited to vegetal and animal sources), which could be investigated in several diseases using in vivo models or described using in vitro assays. Clinical assays are also welcome.
Prof. Dr. Ariane Leite Rozza
Guest Editor
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Keywords
- inflammation
- bioproducts
- isolated compounds
- cytokines
- macrophages
- autoimmune diseases
- in vivo assay
- in vitro assay
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