Nasal Drug and Vaccine Delivery: Opportunities, Advantages and Limitations of Nanomaterials

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 6022

Special Issue Editor


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Guest Editor
Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal
Interests: nanoparticles; bionanomaterials; vaccine adjuvants; polymers; exosomes; hepatitis; therapeutic vaccines; prophylactic vaccines; immunotoxicity; immunotolerance; safety-by-design; quality-by-design; immune response

Special Issue Information

Dear Colleagues,

The advantages of the nasal administration route are well known among the scientific community for both local and systemic drugs. Its ease of access and consequent high patient compliance are attractive features, but the avoidance of the gastrointestinal tract’s harsh conditions and first-pass metabolism surpass the convenience of oral administration. In the vaccine field, the nasal delivery of antigens carries additional advantages, as it is implicated in the generation of a mucosal immune response, which is particularly important for preventing infection by airborne pathogens.

Continuous advances in the nanotechnology field, particularly related to polymeric nanobiomaterials, are greatly associated with the development of new particulate delivery systems for the nasal delivery of drugs and antigens.

This Special Issue welcomes original research papers and review articles highlighting recent developments and innovations in the area of nasal drug delivery. Articles covering the synthesis, development, physicochemical characterization and in vitro and in vivo evaluation of new drug/vaccine delivery systems based on polymeric nanomaterials, designed for the nasal route of administration, are welcomed.

We look forward to receiving your contributions.

Dr. Sandra Jesus
Guest Editor

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Keywords

  • nasal drug and vaccine delivery
  • nanoparticles
  • vaccine adjuvants
  • polymeric nanobiomaterials
  • safety-by-design
  • quality-by-design
  • immunotoxicity and Immunotolerance
  • immune response
  • nasal mucosa permeability

Published Papers (1 paper)

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Review

19 pages, 1404 KiB  
Review
Different Methods and Formulations of Drugs and Vaccines for Nasal Administration
by Junhu Tai, Munsoo Han, Dabin Lee, Il-Ho Park, Sang Hag Lee and Tae Hoon Kim
Pharmaceutics 2022, 14(5), 1073; https://doi.org/10.3390/pharmaceutics14051073 - 17 May 2022
Cited by 20 | Viewed by 5589
Abstract
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailability due to [...] Read more.
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues with parenteral administration. However, nasal administration also has some limitations, such as its low bioavailability due to metabolism on the mucosal surface, and irreversible damage to the nasal mucosa due to the ingredients added into the formula. Moreover, the method of nasal administration is not applicable to all drugs. The current review presents the nasal anatomy and mucosal environment for the nasal delivery of vaccines and drugs, as well as presents various methods for enhancing nasal absorption, and different drug carriers and delivery devices to improve nasal drug delivery. It also presents future prospects on the nasal drug delivery of vaccines and drugs. Full article
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