Enhancing Drug Delivery with Bioactive Substances and Solid Dispersion

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2414

Special Issue Editors


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Guest Editor
Laboratory of Biomaterials and Nanotechnology, University of Sorocaba, Sao Paulo, Brazil
Interests: biomaterial; nanotechnology; drug bioavailability; target delivery; drug encapsulation; agrochemical encapsulation
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Guest Editor
Department Pharmacy, University of São Paulo (USP), Av. Prof. Lineu Prestes 580, Bloco 13, São Paulo 05508-900, SP, Brazil
Interests: drug delivery system; polymers; mucoadhesion; nanotechnology; microparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Solid dispersion technology, the science of dispersing one or more bioactive ingredients in an inert matrix in the solid state, is a relevant strategy for achieving an increased dissolution rate, sustained release, improved bioavailability, and modified solid-state properties of drugs with poor or high water solubility. The overall aim and objectives of this Special Issue are to discuss the fundamentals and methods of the evolution of solid dispersions from a practical point of view. The first scientific publications on solid dispersion technologies were published about 60 years ago; since then, the physical stability of solid dispersions has remained a major challenge. Studies that portray successful preparation practices to improve the stability of solid dispersions with in vitro and in vivo assays are welcome to this Special Issue. These studies will undoubtedly contribute to advancing our understanding and application of solid dispersion technology.

In this Special Issue, original research articles and reviews are welcome to be submitted. Research areas may include, but are not limited to, the following: amorphous solid dispersion, ternary solid dispersion, solid dispersion surfactant-free, solid dispersion loaded in structured systems, and solid dispersion in pharmaceutical dosage forms.

Prof. Dr. Marco Chaud
Prof. Dr. Fernanda Isadora Boni
Guest Editors

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Keywords

  • solid dispersion
  • amorphous solid dispersion
  • solid dispersion bioavailability
  • solid dispersion characterization
  • ternary solid dispersion
  • binary solid dispersion

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Published Papers (1 paper)

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Review

61 pages, 3804 KiB  
Review
Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques
by Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad and Anroop B. Nair
Pharmaceutics 2025, 17(1), 136; https://doi.org/10.3390/pharmaceutics17010136 - 19 Jan 2025
Cited by 3 | Viewed by 1935
Abstract
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges in NS-based drug delivery, [...] Read more.
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges in NS-based drug delivery, particularly for oral, ocular, transdermal, pulmonary, and parenteral routes. The conversion of oral NS into powders, pellets, granules, tablets, and capsules, and their incorporation into film dosage forms to address stability concerns is thoroughly reviewed. This article summarizes key stabilizers, polymers, surfactants, and excipients used in NS formulations, along with ongoing clinical trials and recent patents. Furthermore, a comprehensive analysis of various methods for NS preparation is provided. This article also explores various in vitro and in vivo characterization techniques, as well as scale-down technologies and bottom-up methods for NS preparation. Selected examples of commercial NS drug products are discussed. Rapid advances in the field of NS could resolve issues related to permeability-limited absorption and hepatic first-pass metabolism, offering promise for medications based on proteins and peptides. The evolution of novel stabilizers is essential to overcome the current limitations in NS formulations, enhancing their stability, bioavailability, targeting ability, and safety profile, which ultimately accelerates their clinical application and commercialization. Full article
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