Biomedical Applications of Bioactive Cell Penetrating Peptides and Development of Novel Biologics

Dear Colleagues,

We are particularly honored to invite you to participate in this Special Issue of Pharmaceutics. The scope of this project is defined by accelerated numbers of studies that utilize cell penetrating peptides (CPPs) to achieve effective intracellular delivery of otherwise impermeable agents. As pharmacokinetic modifiers, CPPs convey bioactive agents (peptides, proteins, drug, antibodies, nucleotides, etc.) into intracellular compartments to influence eukaryotic cell biology as novel biologics. The recent FDA endorsement of a CPP/toxin formulation further predicts a promising future for CPPs as both therapeutic and diagnostic agents. This is clearly an exciting developmental period for CPPs in their many guises as the importance of this novel class of synthetic peptide attracts enhanced recognition.

The aim of this Special Issue is to provide impetus to the development of CPP technologies within a biomedical context and provide full coverage of contemporary developments by exploring topics including CPP design and bioengineering, cargo conjugation, modulation of protein–protein interactions and target-specific delivery in vivo. Full details of research methodologies will serve as a reference source to accelerate progress within the field.

For this Special Issue, both original research articles and reviews are welcome. Research areas may include, but are not limited to, the following topics:  selection and design of CPPs, transition of CPPs towards a clinical setting, mechanistic studies of CPPs in eukaryotic cells, therapeutic applications of CPPs for cardiovascular disease and cancer and intracellular targeting of CPP conjugates.

We look forward to receiving your contributions.

Prof. Dr. John Howl
Dr. Sarah Jones
Guest Editors

Manuscript Submission Information

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