Novel Therapeutic Agents and Innovative Delivery Systems Against Infectious Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 908

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Guest Editor
Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale di San Pio V, 44, 00165 Rome, Italy
Interests: drug delivery; medicinal chemistry; drug discovery and development; antimycobacterial agents; antiviral agents; tuberculosis
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Special Issue Information

Dear Colleagues,

Innovative therapeutics against infectious diseases are urgently needed. The lack of a strong pipeline of anti-infective drugs, coupled with the rising prevalence of resistant and emerging pathogens, has led to a worldwide health crisis over the last decade, posing a serious threat to global health systems worldwide. To address these challenges, novel approaches to infectious disease drug development are required. This Special Issue sets out to explore cutting-edge advancements in the discovery of new novel therapeutic agents and innovative drug delivery systems against infectious diseases, particularly those targeting emerging and resistant pathogens. We aim to highlight breakthroughs in the development of small molecules, biologics, vaccines, and advanced drug delivery systems, such as nanocarriers, lipid-based formulations, and targeted delivery strategies.  

We welcome the submission of original research articles and reviews that advance our understanding and treatment of infectious diseases through novel therapies and innovative delivery strategies. The aim is to bring together diverse perspectives from pharmaceutical sciences, including drug discovery, formulation chemistry, pharmacokinetics, and preclinical/clinical development, with a focus on translational research to meet unmet needs in the treatment of infectious diseases. 

Dr. Sara Consalvi
Guest Editor

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Keywords

  • medicinal chemistry
  • antibacterials
  • antivirals
  • antimicrobials
  • drug resistance
  • drug delivery
  • drug candidate
  • drug repurposing

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Published Papers (1 paper)

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Review

38 pages, 4260 KB  
Review
Therapeutic and Formulation Advances of Ivermectin in Veterinary and Human Medicine
by Nicezelle Gernandt, Chanri Wentzel, Daniélle van Staden, Wilna Liebenberg, Hendrik J. R. Lemmer and Minja Gerber
Pharmaceutics 2025, 17(11), 1384; https://doi.org/10.3390/pharmaceutics17111384 - 25 Oct 2025
Viewed by 653
Abstract
The treatment of parasitic infections has evolved in terms of effectiveness and the prevention of drug resistance. This is highlighted by the discovery of ivermectin (IVM), a macrocyclic lactone and broad-spectrum antiparasitic agent. IVM garnered scientific attention by presenting a therapeutic alternative in [...] Read more.
The treatment of parasitic infections has evolved in terms of effectiveness and the prevention of drug resistance. This is highlighted by the discovery of ivermectin (IVM), a macrocyclic lactone and broad-spectrum antiparasitic agent. IVM garnered scientific attention by presenting a therapeutic alternative in the field of veterinary medicine due to its control of multiple parasite species, including nematodes and soil-transmitted helminths. Shortly after its discovery, IVM was approved for human use by the World Health Organization (WHO) and United States Food and Drug Administration (FDA) for combating head lice, onchocerciasis, rosacea, scabies, and worm infestations within the gastrointestinal tract (GIT). In veterinary medicine, IVM is available in a range of formulations and can be administered via different routes (i.e., oral, topical, and parenteral), whereas for humans, IVM is only approved as a single oral dose and dermal cream. Establishing a comprehensive overview of IVM’s applications in both human and veterinary medicine is necessary, particularly in light of its repurposing potential as a treatment for various conditions and emerging diseases. Given its primary application in veterinary medicine, there is a need to enhance the development of dosage forms suitable for human use. Therefore, this review details the discovery, mechanisms, and applications of IVM, while also examining the challenges of resistance, side-effects, and controversy surrounding its use, to ultimately emphasize the importance of targeted, optimized IVM delivery via tailored dosage form development in animals and humans as part of the One Health approach to interlink innovations across veterinary and human medicine fields. Full article
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