Antimicrobial Resistance and Antimicrobial Activity of Bioactive Compounds in Drug Formulations

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 381

Special Issue Editors

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Guest Editor
Department of Infectious Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev Str., 1113 Sofia, Bulgaria
Interests: pathogenic bacteria; food-borne zoonozes; virulence factors; bacteria–host relationships; infectious immunology; molecular biology; ecology of pathogens; new antibacterial agents; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Infectious Microbiology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: antimicrobial agents; antimicrobial resistance; quorum sensing; gene expression; virulence factors

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) to clinically approved antibiotics and chemotherapeutics in human and veterinary medicine has been a global challenge for over 60 years. It has been reported that deaths caused by AMR could increase from 700,000 in 2014 to 10 million by 2050. 

Most antibiotics and chemotherapeutics actively damage cells, and therefore, they cannot completely destroy bacterial cells in biofilms. Biofilm formation is associated with the adhesion, motility, resistance to antibiotics, DNA transfer, autolysis, metabolic activity, etc., abilities of bacteria. These factors are regulated by the expression of genes united in a system called quorum sensing. Inhibitors of this system, respective of gene expression, can be bioactive molecules that do not affect bacterial growth or mimic the action of signaling molecules. This is why the search for and identification of new biologically active molecules of which the action is enhanced by their inclusion in drug formulations are of public health importance. Such carriers can be solid lipid nanoparticles, nanocapsules, liposomes, microemulsion drug delivery systems, etc.

This Special Issue aims to introduce new natural compounds with microbiological activities to conventional delivery systems for the prevention and treatment of infectious diseases in human and veterinary medicine. In this Special Issue, original research articles and reviews are welcome. Research areas may include the isolation of bioactive compounds and their loading into drug delivery systems; evaluation of their antimicrobial in vitro or/and in vivo activity, according to the Ethics and Animal Care Committee; their role in quorum sensing system; and determining their stability for practical use.

I look forward to receiving your contributions.

Prof. Dr. Hristo Najdenski
Dr. Lyudmila Dimitrova
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • new biologically active agents
  • drug delivery systems
  • antibiotic resistance
  • gene expression
  • biofilms
  • quorum sensing
  • in vitro and in vivo models

Published Papers

This special issue is now open for submission.
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