Pharmaceutical Polymorphs and Cocrystals and Their In Vitro and In Vivo Evaluation
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 12911
Special Issue Editors
2. Beijing Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Beijing 100050, China
Interests: new technologies and methods for pharmaceutical analysis; polymorphic drugs; quality control of drugs; druggability evaluation of innovative drug
2. Beijing Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Beijing 100050, China
Interests: solid state pharmaceutical crystal chemistry; application of computational chemistry to pharmaceutical crystallography; evaluation of pharmaceutical cocrystal in vitro and in vivo
Special Issue Information
Dear Colleagues,
Approximately 90% of new chemical entities and 40% of marketed drugs belong to biopharmaceutical classification system (BCS) classes II or IV, which have poor water solubility and/or poor permeability. These defects result in low bioavailability. The formation of different polymorphs and co-crystals has been proven to be an important method to effectively improve the physicochemical properties, in vivo metabolic processes and bioavailability of these insoluble compounds. Through the efforts of many researchers, many new polymorphs or co-crystals of these compounds have been discovered. Some of them, such as Entresto (sacubitril valsartan sodium tablet, the first co-crystal drug approved by the FDA) and Seglentis (tramadol hydrochloride and celecoxib), after rigorous preclinical research and clinical trials, have been marketed for clinical service. The research on the polymorphs and co-crystals of these compounds provides new approaches and broad prospects for drug development.
The efficient design, screening and preparation of different polymorphs and co-crystals of drugs, and accurate and scientific evaluation of their physical and chemical properties and in vitro and in vivo processes are the key points in drug research and development. We encourage the submission of research studies exploring these topics to this Special Issue. The different solid states of chemicals affect their physicochemical properties (e.g., solubility, permeability and stability) and in vivo processes (e.g., absorption and distribution), thus affecting bioavailability. Through systematic studies, the optimal crystal forms or co-crystals of drugs can be screened to improve their medicinal properties. This Special Issue aims to explore new research ideas for enriching material resources and promoting drug research and development.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Drug permeability improvement and in vitro and in vivo evaluation;
- Solubility improvement of insoluble drugs and in vitro and in vivo evaluation;
- Study on the mechanisms of improvement of physical and chemical properties of different drug polymorphs or co-crystals;
- New methods for evaluating the solubility and permeability of different drug polymorphs or co-crystals;
- Studies on pharmacokinetics of different drug polymorphs or co-crystals in vivo.
We look forward to receiving your contributions.
Prof. Dr. Li Zhang
Prof. Dr. Dezhi Yang
Guest Editors
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Keywords
- pharmaceutical polymorphs
- pharmaceutical cocrystals
- pharmaceutical salts
- solubility
- dissolution
- permeability
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