Antibiotic Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 10 October 2025 | Viewed by 2982

Special Issue Editors


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Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Cromore Road, Londonderry BT52 1SA, UK
Interests: clinical pharmaceutics; polymeric formulation; diagnostics; drug delivery; vaccination; antimicrobial stewardship
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Cromore Road, Londonderry BT52 1SA, UK
Interests: bio-active glass; controlled release; pharmaceutics; release kinetics; antimicrobial resistance and stewardship; prescribing patterns

E-Mail Website
Guest Editor
School of Pharmacy and Pharmaceutical Sciences, Ulster University, Cromore Road, Londonderry BT52 1SA, UK
Interests: biomaterials; medical device-associated infections; drug delivery; antimicrobial resistance; synergistic approaches; biofilm

Special Issue Information

Dear Colleagues,

Pharmaceutics is excited to present a Special Issue focusing on "Antibiotic Drug Delivery Systems".

Antimicrobial resistance poses a significant threat to global health, necessitating innovative strategies for the delivery and administration of antibiotics. This Special Issue "Antibiotic Drug Delivery Systems" aims to highlight recent advancements and explore new methodologies in the targeted and efficient delivery of antibiotics. By focusing on novel drug carriers, such as nanoparticles, liposomes, and prodrugs, alongside intelligent design principles that enhance solubility, stability, and tissue penetration, this collection of research articles and reviews addresses the critical need for improved therapeutic efficacy and reduced side-effects. This Special Issue also delves into the importance of understanding the mechanisms by which these systems interact with pathogens and the host immune response, paving the way for more personalized and effective treatments. As we stand at the precipice of a post-antibiotic era, this compilation underscores the importance of multidisciplinary approaches in combating resistance and restoring the power of life-saving drugs. This Special Issue serves not only as a state-of-the-art overview but also as a beacon guiding future research directions in antibiotic delivery systems.

In this Special Issue, original research articles and reviews are welcome to be submitted. We look forward to receiving your contributions.

Dr. Aaron J. Courtenay
Dr. Deborah Lowry
Dr. Jessica V. Moore
Guest Editors

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Keywords

  • antibiotic drug delivery
  • antimicrobial resistance
  • targeted drug carriers
  • nanoparticles
  • liposomes
  • prodrug systems
  • drug solubility and stability
  • synergistic approaches
  • biofilm targeting
  • host–pathogen interaction
  • personalized antibiotic therapy

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Published Papers (1 paper)

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Review

29 pages, 3840 KiB  
Review
Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance
by Tarequl Islam, Noshin Tabassum Tamanna, Md Shahjalal Sagor, Randa Mohammed Zaki, Muhammad Fazle Rabbee and Maximilian Lackner
Pharmaceutics 2024, 16(12), 1542; https://doi.org/10.3390/pharmaceutics16121542 - 2 Dec 2024
Cited by 6 | Viewed by 2687
Abstract
The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the capacity to enhance [...] Read more.
The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the capacity to enhance human immunity. AMPs are being developed as potential medicines, and current computational and experimental tools aim to facilitate their preclinical and clinical development. Structural and functional constraints as well as a more stringent regulatory framework have impeded clinical translation of AMPs as possible therapeutic agents. Although around four thousand AMPs have been identified so far, there are some limitations of using these AMPs in clinical trials due to their safety in the host and sometimes limitations in the biosynthesis or chemical synthesis of some AMPs. Overcoming these obstacles may help to open a new era of AMPs to combat superbugs without using synthetic antibiotics. This review describes the classification, mechanisms of action and immune modulation, advantages, difficulties, and opportunities of using AMPs against multidrug-resistant pathogens and highlights the need and priorities for creating targeted development strategies that take into account the most cutting-edge tools currently available. It also describes the barriers to using these AMPs in clinical trials. Full article
(This article belongs to the Special Issue Antibiotic Drug Delivery Systems)
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