Challenges and Future Trends of Nano-Based Drug Delivery System in the Treatment of Bone Diseases
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 2154
Special Issue Editors
Interests: biomaterials; extracellular vesicles; bone and joint degeneration
Special Issue Information
Dear Colleagues,
With the intensification of global population aging, the prevalence of bone diseases among middle-aged and elderly individuals worldwide remains significantly high. The development of advanced nano-biomaterials and novel pharmacological treatments to effectively treat various bone diseases, including osteoporosis, osteoarthritis, and osteoporotic fractures, presents a substantial challenge for contemporary osteopathology research. Through comprehensive investigations into the molecular and cellular mechanisms underlying bone diseases, the development of targeted therapeutics and advanced drug delivery platforms has emerged as a novel paradigm in the treatment of these conditions. Nanomedicine delivery systems have been extensively utilized within this field, exhibiting exceptional performance. The design and therapeutic application of these delivery systems are advancing rapidly, encompassing areas such as nanomedicine carriers, delivery mechanisms, safety and efficacy evaluations, and the clinical application of nanomedicine materials. Despite ongoing advancements in research, the nano-based drug delivery system continues to encounter numerous challenges within the emerging field of intelligent medicine. Key issues that require further investigation include the biocompatibility, stability, and immune response of drug carriers. Additionally, the therapeutic efficacy of these delivery systems must be rigorously evaluated in vivo or ex vivo to ensure their suitability for future clinical applications.
This Special Issue will cover all the advances, challenges, and future perspectives in using nano-based drug delivery system to manage bone diseases (e.g., osteoporosis, osteoarthritis, fracture defect, bone tumors, etc.). Original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Research, policy, and trends related to the design of nanobiomedical materials and the therapeutic application of bone diseases.
- Stimuli-responsive nano-biomedical materials functioning as drug carriers in bone disease.
- Nano-drugs or nanocarriers in pharmacy of bone diseases, including polymer drug carriers, drug release, targeted therapy, and drug metabolism.
- Bone disease therapeutic nano-biomaterials facilitating efficient delivery of therapeutic agents such as drugs, genes, and proteins.
- Biopolymers, nanocomposites, nano micelles, polymersomes, and liposomes employed as drugs or drug carriers for bone disease therapy.
We look forward to receiving your contributions.
Dr. Xiao Lin
Dr. Jie Shang
Guest Editors
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Keywords
- nano-based drug delivery system
- drug delivery particles
- controlled release
- stimuli-responsive drug delivery system
- photodynamics therapy
- nanozymes
- organic porous materials
- osteoporosis
- fracture healing
- osteoarthritis
- bone tissue regeneration
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