Pharmaceutical Dosage Forms: Drug Release, Solubility and Stability Evaluation

Dear Colleagues,

The release of drugs from the formulations is an important process in both immediate release and modified release dosage forms since it governs the efficiency of the pharmaceutical dosage forms. It also plays a crucial role in the design and optimization of modified release dosage forms including sustained, controlled, and delayed release forms and novel drug delivery systems. One of the most critical and important parameters impacting drug release is drug solubility, an essential property of a drug substance, vital for its bioavailability. Poor solubility can lead to low bioavailability and results in sub-optimal drug delivery, being a significant impediment to drug development efforts.

In the two past decades, the use of sophisticated experimental techniques, advanced computational methods, and complementary technologies in the drug discovery process has led to poor water solubility for nearly 60%‒90% of the developmental pipeline drugs and almost 40% of approved drugs. Nowadays, a lot of studies involve different approaches for enhancing the solubility of poorly water-soluble drugs and the design and development of modified drug delivery systems with optimized biopharmaceutics, pharmacokinetic and pharmacodynamics properties of drugs.

This Special Issue aims at collecting research covering drug solubility along with techniques and strategies addressing low solubility of active substances, drug release, modified drug delivery systems and issues related to drug stability, including drug-excipient interaction, being known the major importance in the selection of suitable excipients in the drug development process for the efficiency, quality, safety and stability of pharmaceutical dosage forms. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Laura Sbârcea
Prof. Dr. Adriana Violeta Ledeți
Dr. Valentina Oana Buda
Dr. Denisa Laura Cîrcioban
Guest Editors

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