Innovations in Advanced Drug Delivery Systems: Overcoming Challenges for Personalized Medicine
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 934
Special Issue Editor
Interests: chalcones; natural products; antimicrobial activity; zebrafish; anxiolytic activity; spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pursuit of more effective therapies is constantly reshaping medicine. Traditional drug administration often suffers from poor bioavailability, systemic toxicity, and a lack of targeted delivery. Advanced drug delivery systems (ADDSs) offer a promising solution, but realizing their potential faces significant obstacles. Biological barriers pose a major challenge, requiring ADDS carriers like nanoparticles to navigate the bloodstream, evade the immune system, and cross cellular membranes. This necessitates precise engineering to optimize size, shape, surface charge, and targeting ligands for enhanced circulation, reduced off-target effects, and improved cellular uptake. Scalability is another hurdle, as laboratory-developed systems often prove difficult and costly to mass-produce consistently. Reproducibility, stability, long-term storage, and stringent regulatory requirements further complicate the manufacturing of ADDSs. Despite these challenges, ADDSs hold immense potential for personalized medicine.
We look forward to receiving your contributions.
Dr. Hélcio Silva Dos Santos
Guest Editor
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Keywords
- drug administration
- polymers
- structural characterization
- nanoparticles
- in silico studies
- toxicity
- bioavailability
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