Advanced Drug Delivery Systems for Natural Products

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 334

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria
Interests: emulsion polymerization; drug stability; pharmaceutical nanotechnology; pharmaceutical research and development; pharmacokinetics
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9000 Varna, Bulgaria
Interests: vesicular systems; niosomes; stimuli-sensitive nanocarriers; inorganic nanoparticles
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University of Varna, 9002 Varna, Bulgaria
Interests: natural products; phytotherapy; HPLC; in vivo modeling; pharmacology; toxicology; pharmacokinetics

Special Issue Information

Dear Colleagues,

Even in the era of technological advancement, natural products play a pivotal role in drug development, offering a vast repertoire of bioactive molecules with diverse pharmacological properties. However, their clinical potential is often constrained by their poor solubility and permeability, low bioavailability, rapid metabolism, and instability.

In recent decades, interdisciplinary efforts spanning chemistry, physics, biology, mathematics, technology, and biomedical sciences have driven the successful development of advanced drug delivery systems (ADDSs). These innovations enable the precise targeting of complex biological sites while ensuring optimal concentrations of bioactive compounds at the right time and for the appropriate duration. Such advancements undoubtedly refine the pharmacokinetic and/or pharmacodynamic profiles of encapsulated natural products. Additionally, patient compliance is enhanced, while safety is improved by administering lower doses, reducing drug exposure, and limiting distribution to non-target tissues, among other benefits. Nevertheless, the development of ADDSs continues to encounter challenges that require further investigation and remain a central focus of intense scientific inquiry.

The Pharmaceutics Special Issue, entitled “Advanced Drug Delivery Systems for Natural Products”, aims to present the latest advancements in this field. We invite all interested researchers to submit their innovative approaches (original research articles or comprehensive reviews), which will contribute to expanding knowledge in this rapidly developing area.

Dr. Velichka Andonova
Dr. Viliana Eduardova Gugleva
Dr. Stanila Stoeva
Guest Editors

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Keywords

  • natural products
  • advanced drug delivery systems
  • liposomes
  • niosomes
  • phytosomes
  • lipid nanoparticles
  • smart polymers
  • biodegradable nanoparticles
  • polymeric nanoparticles
  • drug carriers

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Published Papers (1 paper)

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Research

46 pages, 7647 KB  
Article
Harnessing Nature for Breast Cancer Management: Effects of Fisetin-Loaded Nigellasomes Embedded in Microneedles Improve Tumor Suppression and Reduce Oxidative Stress
by Sammar Fathy Elhabal, Eman Mohammed Ali, Sandra Hababeh, Fatma E. Hassan, Suzan Awad AbdelGhany Morsy, Dalia Ahmed Elbahy, Sahar K. Ali, Khaled M. Allam, Ibrahim Mousa, Marwa A. Fouad and Ahmed Mohsen Elsaid Hamdan
Pharmaceutics 2025, 17(11), 1392; https://doi.org/10.3390/pharmaceutics17111392 - 27 Oct 2025
Abstract
Background: Natural compounds such as fisetin have promising in breast cancer treatment, but their poor pharmacokinetics limit their therapeutic application. This study utilized a synergistic approach by combining fisetin-loaded Nigella sativa (N.S.) oil nanovesicles (FIS-NSs) and carbohydrate-based microneedles (FIS-NSs-MNs) to improve breast [...] Read more.
Background: Natural compounds such as fisetin have promising in breast cancer treatment, but their poor pharmacokinetics limit their therapeutic application. This study utilized a synergistic approach by combining fisetin-loaded Nigella sativa (N.S.) oil nanovesicles (FIS-NSs) and carbohydrate-based microneedles (FIS-NSs-MNs) to improve breast cancer management. Methods: Chemical composition of NS petroleum ether extract using gas chromatography–mass spectrometry (GC/MS). FIS-NSs were prepared and characterized for particle size, polydispersity, zeta potential, encapsulation efficiency, and stability. These vesicles were embedded into gelatin, hyaluronic acid, and carboxymethyl cellulose microneedles. In vitro drug release, ex vivo permeation, cytotoxicity against breast cancer cells, and in vivo antitumor efficacy in Ehrlich tumor models were evaluated. Results: Optimized FIS-NSs displayed nanoscale size (190 ± 0.74 nm), low P.D.I (0.25 ± 0.07), high surface charge (+37 ± 0.57 mV), and high encapsulation (88 ± 0.77%). In vitro investigations showed sustained FIS release (~85% over 72 h), while ex vivo permeation showed higher absorption than free fisetin. Both FIS-NSs and FIS-NSs-MNs showed dose-dependent cytotoxicity against breast cancer cells, with lower IC50 than free fisetin (24.7 µM). In vivo, FIS-NSs-MNs and tumor burden inhibition (~77%), reduced oxidative stress (54%), restored antioxidant defenses, and decreased inflammatory markers. Immunohistochemical analysis for caspase-3 showed apoptosis activation within tumor tissues. Conclusions: These findings demonstrate that FIS administration via NS-MNs improves drug stability, penetration, and apoptotic activity, resulting in enhanced anticancer effects. This innovative nanovesicle–microneedle platform provides a non-invasive, effective, and patient-friendly approach for the effective treatment of breast cancer, with potential for broader applications in oncological nanomedicine. Full article
(This article belongs to the Special Issue Advanced Drug Delivery Systems for Natural Products)
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