Nanoparticles for Glioblastoma Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1448

Editors


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Guest Editor
School of Bioengineering, IQS, Ramon Llull University, 08017 Barcelona, Spain
Interests: nanoparticles; biomaterials; gene delivery; glioblastoma; cancer stem cells; blood–brain barrier
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Bioengineering, IQS, Ramon Llull University, Barcelona, 08017
Interests: drug delivery; peptide and protein chemistry; antibody engineering; blood–brain barrier
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Glioblastoma (GBM) remains a formidable challenge with limited therapeutic options and poor prognosis. Nanoparticle-based drug delivery systems offer a promising avenue to overcome obstacles in GBM treatment, including the blood–brain barrier (BBB) and tumor heterogeneity.

This Special Issue highlights the potential of nanoparticles for enhancing GBM therapy. We invite contributions exploring how nanoparticles can be engineered to improve drug penetration across the BBB, selectively target tumor cells, and enable controlled drug release. We also welcome submissions on various nanoparticle types, including lipid-based, polymeric, and inorganic nanoparticles, and their application in delivering chemotherapeutic agents, gene therapies, and other therapeutic modalities.

Furthermore, we encourage submissions presenting preclinical studies that demonstrate the ability of nanoparticles to enhance GBM treatment efficacy by increasing drug concentration at the tumor site, reducing systemic toxicity, and overcoming drug resistance mechanisms. Submissions focusing on functionalized nanoparticles with specific ligands or antibodies for active GBM cell targeting are also highly encouraged. This Special Issue aims to gather cutting-edge research that will advance the translation of these promising findings into clinical applications and ultimately improve the survival and quality of life of individuals with GBM.

The Special Issue of Pharmaceutics invites submissions related to drug delivery systems, innovative formulations, nanomedicine, and targeted therapy. The Special Issue of Biomedicines encourages contributions centered on biological aspects.

You may choose our Joint Special Issue in Biomedicines.

Dr. Shambhavi Pandey
Dr. Benjamí Oller-Salvia
Guest Editors

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Keywords

  • nanoparticles
  • blood–brain barrier
  • gene delivery
  • glioblastoma
  • cancer stem cells
  • biomaterials

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Published Papers (1 paper)

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Research

37 pages, 10705 KB  
Article
Folic Acid-Guided PLGA-Zein Core–Shell Nanoparticles for Co-Delivery of Temozolomide and Ellagic Acid to Overcome PARP-Mediated Chemoresistance in Glioblastoma
by Arunraj Tharamelveliyil Rajendran, Ashwini Prabhu, Ashwini Madhava and Anoop Narayanan Vadakkepushpakath
Pharmaceutics 2026, 18(6), 655; https://doi.org/10.3390/pharmaceutics18060655 - 27 May 2026
Viewed by 838
Abstract
Background: Glioblastoma (GBM) remains a lethal malignancy due to temozolomide (TMZ) resistance and limited drug penetration across the blood–brain barrier, largely driven by hyperactive DNA damage repair mechanisms such as poly (ADP-ribose) polymerase (PARP). To address these challenges, we developed folic acid-targeted PLGA–zein [...] Read more.
Background: Glioblastoma (GBM) remains a lethal malignancy due to temozolomide (TMZ) resistance and limited drug penetration across the blood–brain barrier, largely driven by hyperactive DNA damage repair mechanisms such as poly (ADP-ribose) polymerase (PARP). To address these challenges, we developed folic acid-targeted PLGA–zein hybrid core–shell nanoparticles for the codelivery of the alkylating agent TMZ and the natural PARP inhibitor Ellagic acid (FA-TMZ/EA-PZ-CS NPs), thereby enabling simultaneous enhancement of drug delivery and suppression of chemoresistance pathways. Methods and Results: The dual-drug nanoplatform was fabricated using a double-emulsion solvent evaporation method and functionalized via EDC/NHS-mediated folic acid conjugation to promote receptor-mediated uptake. Physicochemical characterisation confirmed uniform spherical morphology, high colloidal stability, efficient drug encapsulation, and sustained biphasic drug release consistent with a core–shell diffusion mechanism. In LN229 glioblastoma cells, folic acid conjugation significantly enhanced cellular internalisation and cytotoxic efficacy compared to free drugs and non-targeted nanoparticles. Combination index analysis revealed strong synergism between TMZ and ellagic acid, resulting in markedly reduced IC50 values. Mechanistic studies demonstrated apoptosis induction, increased DNA damage, inhibition of cell migration at sub-cytotoxic concentrations, and downregulation of PARP gene expression. Conclusion: Overall, this study establishes a targeted core–shell nanotherapeutic strategy that integrates chemotherapy with DNA repair inhibition to overcome TMZ resistance, offering a mechanistically sound strategy that serves as a foundational framework for future translational research. Full article
(This article belongs to the Special Issue Nanoparticles for Glioblastoma Therapy)
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