Solid Dispersions for Oral Delivery: Materials, Technologies, Characterization, and Translation
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 25 March 2027 | Viewed by 1456
Special Issue Editors
Interests: pharmaceutical technology; drug design; quality by design
Interests: biopharmaceutics; pharmacokinetics; pharmaceutical technology
Interests: analytical method development and validation; quality control of health products; drug delivery; cosmetics; nutricosmeticsș nutraceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the design, preparation, characterization, and translational development of solid dispersion systems for improving the oral delivery of poorly soluble active pharmaceutical ingredients. We welcome contributions on amorphous and crystalline solid dispersions, supersaturating drug delivery systems, and related formulation strategies intended to enhance solubility, dissolution, stability, permeability, and oral bioavailability. Topics of interest include carrier and excipient selection, drug–polymer miscibility, precipitation inhibition, advanced manufacturing technologies such as hot-melt extrusion, spray drying, electrospinning, freeze-drying, and solvent-based methods, as well as solid-state characterization and stability assessment. Studies addressing biorelevant dissolution, in vitro–in vivo correlations, pharmacokinetics, quality-by-design, scale-up, manufacturability, and regulatory considerations are also encouraged. Original research articles, reviews, and short communications that combine mechanistic insight with practical formulation development are particularly welcome.
Dr. Andrei Cătălin Muntean
Dr. Andreea Loredana Vonica-Tincu
Dr. Luca-Liviu Rus
Guest Editors
Manuscript Submission Information
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Keywords
- solid dispersions
- amorphous solid dispersions
- supersaturating drug delivery systems
- poorly soluble drugs
- BCS class II and IV drugs
- solubility enhancement
- dissolution enhancement
- oral bioavailability
- oral absorption
- drug–polymer miscibility
- precipitation inhibition
- polymer carriers
- hot-melt extrusion
- spray drying
- electrospinning
- freeze-drying
- solid-state characterization
- physical stability
- biorelevant dissolution
- IVIVC
- pharmacokinetics
- quality by design
- scale-up
- regulatory science
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