Technology and Preparation of Solid Dispersion for the Enhancement of Oral Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 57
Special Issue Editors
Interests: pharmaceutical technology; drug design; quality by design
Interests: biopharmaceutics; pharmacokinetics; pharmaceutical technology
Interests: analytical method development; analytical method validation; NIR Spectroscopy; chemometrics; quality control of health products; drug delivery; cosmetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of Pharmaceutics, entitled “Technology and Preparation of Solid Dispersion for the Enhancement of Oral Bioavailability”, aims to highlight both foundational and emerging advancements in the field. It brings together contributions that span formulation design, process technologies, characterization methods, and translational applications. The research presented herein reflects the ongoing evolution of solid dispersion strategies as a cornerstone of modern oral drug delivery.
Key themes explored in this Special Issue include the following:
- Innovative Preparation Methods: Contributions cover state-of-the-art fabrication techniques such as hot-melt extrusion, spray drying, electrospinning, freeze-drying, and solvent evaporation. These processes are critical for achieving uniform drug–polymer dispersion, scalable manufacturing, and robust performance.
- Rational Formulation Design: Studies delve into the physicochemical and thermodynamic principles underlying drug–polymer miscibility, the stabilization of amorphous states, and the role of excipients and surfactants in enhancing solubility and maintaining supersaturation post-administration.
- Characterization and Stability: This Special Issue emphasizes the importance of analytical techniques—such as X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and solid-state nuclear magnetic resonance (ssNMR)—to characterize molecular dispersion, assess physical stability, and understand drug–excipient interactions at the molecular level.
- In Vitro and In Vivo Performance: Several contributions are invited to examine dissolution testing in biorelevant media, pharmacokinetic evaluation, and the establishment of in vitro–in vivo correlations (IVIVCs) to predict bioavailability outcomes and support rational product development.
- Regulatory and Industrial Perspectives: Articles also address scalability, process control, long-term stability under ICH guidelines, and regulatory considerations critical for the successful commercialization of solid dispersion-based products.
Dr. Andrei Cătălin Muntean
Dr. Andreea Loredana Vonica-Tincu
Dr. Luca-Liviu Rus
Guest Editors
Manuscript Submission Information
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Keywords
- solid dispersions
- poor water solubility
- rational formulation design
- enhancement of oral bioavailability
- preparation technology
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