Cell Penetrating Peptides as Potential Therapeutic Agents
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 1937
Special Issue Editors
Interests: membrane biophysics; bioactive peptides; advanced techniques in biophysics; biophysics and molecular biology; infrared spectroscopy
Special Issues, Collections and Topics in MDPI journals
Interests: structure determination of biological macromolecules; X-ray diffraction and electron microscopy; interaction of molecules of biological interest with cell membranes
Special Issue Information
Dear Colleagues,
Membranes are barriers that provide an outer boundary for cells (plasma membranes) as well as their inner compartments (organelles). Membranes control the flow of information between cells, either by recognizing signal molecules received or by sending chemical or electrical signals to other cells. Therefore, biological membranes are more than just inert barriers or covers; they play active roles in the life of the cells. Many molecules, directly or indirectly, influence cell membrane properties; among these molecules, bioactive peptides have become relevant since they have shown a wide range of activities, including antibacterial, anticancer, antivirus, antiparasitic, antifungal, and also biofilm activity. The advances in peptides have centered the attention on a family of short peptides named cell-penetrating peptides (CPPs). The most accepted mechanism of action of bioactive peptides is related to membrane destabilization and disruption. For this reason, understanding how peptides interact with biological membranes and exert their activity at the molecular level is of critical significance in the pharmacological and biological fields.
This Special Issue aims to gather contributions related to the potential therapeutic use of CPP membrane models and biophysical techniques to better understand the peptide–membrane interaction, study of the mechanism of action, and potential therapeutic applications of bioactive peptides. Submissions on the discovery of new peptides or novel activities of well-known peptides are also encouraged.
All submission types, including original research articles and comprehensive reviews, are welcome.
Dr. Marcela Manrique Moreno
Prof. Dr. Mario Suwalsky
Guest Editors
Manuscript Submission Information
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Keywords
- cell-penetrating peptides (CPPs)
- membrane-active peptides
- biophysical techniques
- lipid–peptide interaction
- peptide mechanism of action
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