Natural Product-Based Pharmaceutical Formulations for Skin Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 430

Editors


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Guest Editor
Department of Pharmaceutical Sciences, Collegium Medicum, Jan Kochanowski University, IX WiekówKielc 19, 35-317 Kielce, Poland
Interests: pharmaceutics; natural products; topical delivery
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal
2. REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal
Interests: drug delivery; drug; nanosystems

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue, “Natural Product-Based Pharmaceutical Formulations for Skin Drug Delivery”.  Skin represents the largest organ of our body that works as a barrier of protection. For these reasons, it is of utmost importance to maintain its integrity and function. Moreover, the skin serves as a route for the delivery of active ingredients, aiming for both topical application and systemic delivery. For an effective delivery through the skin, various dosage forms have been developed since ancient times. Natural products—acting as both active ingredients and excipients—are a focal point in pharmaceutical sciences, particularly for products applied to the skin. Expanding research in this field is essential to validate its pharmaceutical potential and safety. Furthermore, natural products offer a sustainable pathway through the upcycling of agro-industrial by-products.

This Special Issue aims to outline the recent and most impactful research on natural product-based pharmaceutical formulations aiming for skin delivery. Furthermore, it seeks to highlight the role of natural products both as active ingredients and as excipients in the development of innovative formulations. We invite original research and review articles across a broad range of interests, including (but not limited to) the following: natural compounds, hemi-synthetic compounds derived from plants, mushrooms, marine sources, or agroindustrial by-products applicable to skin through conventional dosage forms, and innovative drug delivery systems, including nano and smart systems.

We look forward to receiving your contributions.

Dr. Monika Michalak
Dr. Amélia Vieira
Guest Editors

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Keywords

  • natural products
  • topical drug delivery systems
  • skin permeation
  • nanotechnology
  • skin care and therapy
  • wound management

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Published Papers (1 paper)

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33 pages, 1319 KB  
Systematic Review
A Systematic Review of Recent Developments in Wound Healing and Skin Regeneration Properties of Plant-Extract-Based Hydrogels for Skin Delivery: A Focus on Asteraceae and Lamiaceae Families
by Monika Michalak
Pharmaceutics 2026, 18(9), 1047; https://doi.org/10.3390/pharmaceutics18091047 (registering DOI) - 23 Aug 2026
Abstract
Background: Plants have been traditionally used for centuries to treat wounds and, over time, have been tested for their healing properties. There is a constant search for new natural resources that could be used to develop various topical wound care products. Methods: A [...] Read more.
Background: Plants have been traditionally used for centuries to treat wounds and, over time, have been tested for their healing properties. There is a constant search for new natural resources that could be used to develop various topical wound care products. Methods: A comprehensive search of the literature was conducted in PubMed/MEDLINE, Scopus, and Web of Science databases (2022–2026) in accordance with the PRISMA 2020 guidelines. Included studies focused on current in vitro and in vivo research on hydrogels containing plant extracts from the Asteraceae and Lamiaceae families and their potential application in wound healing and skin regeneration. Results: An analysis of 24 included studies confirms that both families include interesting and valuable plants with antioxidant, antimicrobial and anti-inflammatory properties; these plants also influence collagen deposition, fibroblast proliferation, and epithelialization, and reduce the risk of infection, thereby contributing to faster wound healing. The most frequently tested phytoextract in this respect was Calendula officinalis (Asteraceae) incorporated into a hydrogel. A variety of materials, including natural, semi-synthetic, and synthetic polymers, as well as hybrid matrix, but also diverse formulation strategies, from simple solutions to more advanced and modern methods, have been used to produce hydrogels. Conclusions: This systematic review summarizes the current evidence, highlights directions and possibilities for the use of phytoextract-based hydrogels, and discusses limitations and future perspectives in the development of effective externally applied formulations to support wound healing. Full article
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