Novel Antimicrobial Drug and Formulation Design: Overcoming Antimicrobial Resistance and Exploring Combination Therapies
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 52
Special Issue Editors
Interests: antimicrobial agents; antimicrobial resistance; quorum sensing; gene expression; virulence factors
Special Issues, Collections and Topics in MDPI journals
Interests: pathogenic bacteria; food-borne zoonozes; virulence factors; bacteria–host relationships; infectious immunology; molecular biology; ecology of pathogens; new antibacterial agents; antimicrobial resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Increasing levels of antimicrobial resistance (AMR) pose a critical health threat, making it increasingly difficult to both treat and control the spread of infections. The data on AMR are alarming: in 2019, nearly 5 million deaths were attributed to bacterial resistance, with projections indicating a doubling by 2050 if adequate measures are not taken. The COVID-19 crisis has catalyzed the problem by increasing antibiotic use, leading to multidrug resistance and high mortality—all of which have reinforced the urgent need for effective strategies against AMR, such as the development of new antibiotics or effective alternative treatments.
This Special Issue aims to introduce the antimicrobial activities of new compounds or natural products included in drug formulations, as a way of overcoming AMR. The main areas of research include the development of new antimicrobial agents – from their synthesis, respective isolation and formulation into drug delivery systems, through laboratory tests for efficacy and toxicity – in vitro and in vivo according to ethical requirements. Given the importance of antimicrobials, modern studies reveal the genetic basis of this phenomenon and the possible mechanisms of spread. The combined use of a number of new and classical antimicrobial agents is the basis of additive, synergistic, etc., effects. Studies of AMR mechanisms (including biofilms, bacterial quorum-sensing systems, 3D modelling, etc.) and ensuring their stability for clinical use are highly recommended. We encourage the publication of original scientific articles and reviews on this topic.
We look forward to receiving your contributions.
Dr. Lyudmila Dimitrova
Prof. Dr. Hristo Najdenski
Guest Editors
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Keywords
- new biologically active agents
- drug delivery systems
- antimicrobial resistance
- 3D tissue and bacterial biofilm models
- quorum sensing and quorum quenching
- in vivo experiments
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