PI3K: From Basic Science to Clinical Translation

Dear Colleagues,

This Special Issue focuses on new functions and/or new discoveries in the regulation of phosphoinositide kinases and phosphatases. It encompasses the functions of inositol lipids and their molecular species, the consequences of a deregulation of phosphoinositide metabolism in human diseases, and the drugs that have been generated to interfere with their function in disease.

Basic science investigations continue to provide new insight into molecular medicine and clinical and translational sciences, while good progress has been achieved in PI3K pathway drug development, with several PI3K inhibitors now approved for oncology and several others in the approval and registration pipeline. Pharmaceuticals invites both reviews and original articles highlighting the molecular basis of PI3K in health and disease as well as opportunities for, and the development of, new therapeutics, quantitative diagnostic/prognostics, and strategies for targeting the PI3K pathway.

Prof. Stephen Ward
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Inflammation
• Cancer
• Metabolism
• Neurobiology
• Cardiovascular biology
• Translational science
• Therapeutics and molecular medicine
• Immunology

• PI3 Kinase Inhibitors in Pharmaceuticals (2 articles)
• Kinins and Their Receptors as Potential Therapeutic Targets —— A Tribute to Professor Domenico Regoli, A Key Figure in the Field of Kinins in Pharmaceuticals (10 articles)