Cocrystals in Formulation Sciences
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 601
Special Issue Editor
2. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China
3. Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-Based Active Substances, Northeast Forestry University, Harbin 150040, China
Interests: pharmaceutical chemistry; natural products; drug crystals; nanomedicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cocrystals are crystalline substances formed through non-covalent bond interaction between donors and acceptors in a certain stoichiometric ratio, which not only have simple preparation methods, but also could demonstrate different physicochemical properties, such as, packing, melting point, density, crystal shape, optical performance and kinetic parameters. Over the last decade, the pharmaceutical industry has been showing interest in cocrystals due to their ability to improve active pharmaceutical ingredients’ (API’s) properties, such as solubility, dissolution, bioavailability, stability and processability. This class of engineered material offers the advantage that the modification of the drug is at the supramolecular level (van der Waals contact forces, π stacking, hydrogen bonding, electrostatic interaction and halogen bonding) without altering the structure of the drug. At present, pharmaceutical cocrystals have seen immense growth, and a large number of patents related to cocrystals have been filed and approved. However, the metabolism, safety and pharmacodynamic activity of cocrystal drugs in vivo still need to be explored by more researchers. Thereby, the rational design of innovative cocrystals will open up endless opportunities for the use and production of cocrystals. In addition, numerous applications of cocrystals in other areas should be investigated.
The journal Pharmaceuticals invites scientists to submit original papers or reviews, which will be published in a Special Issue on “Cocrystals in Formulation Sciences”. This Special Issue aims to collect the following related topics: molecular modelling, targeting delivery, bioimaging, diagnostic therapy, molecular dynamics, and the bioactive and pharmaceutical chemistry of cocrystals.
Dr. Xiuhua Zhao
Guest Editor
Manuscript Submission Information
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Keywords
- molecular modelling
- targeting delivery
- bioimaging
- diagnostic
- therapy
- molecular dynamics
- bioactive
- pharmaceutical chemistry
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