Special Issue "Mosquito–Microbiota Interactions: Ecology, Evolution and Consequences for Pathogen Transmission"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 1 July 2020.

Special Issue Editor

Assoc. Prof. Claire Valiente-Moro
Website
Guest Editor
UMR CNRS 5557 Microbial Ecology, Lyon1 University, France
Interests: microbial ecology; symbiosis; insect–microbiota interactions

Special Issue Information

Dear Colleagues,

According to the World Health Organization (WHO), mosquitoes are the greatest threat to public health. Their ability to carry and spread diseases to humans causes millions of deaths every year. In the absence of a vaccine for most mosquito-borne pathogens, prevention efforts are currently limited to vector control measures, which have proven difficult to sustain in the long term. In this context, integrated studies on the biology of mosquito vectors are needed to support the development of innovative control strategies. It is now recognized that the biology of a host cannot be fully understood without taking into account its associated microbiota. In the past, numerous studies have described the mosquito-associated microbiota in terms of species composition and their variation factors. In recent years, there has been a growing interest to decipher the biological functions shared by associated microbes. It has become clear that the symbiotic microbiota of mosquito vectors play an important role in their vectorial capacity. Importantly, the native gut microbiota of mosquitoes can modulate their vector competence for human pathogens. However, the mechanisms underlying these complex multipartite interactions (host–microbiota–infectious pathogens) remain to be deciphered. The microbial gut communities of mosquitoes could contribute to several other biological functions which deserve further exploration. Moreover, deciphering the intricate interactions between microbes, host, and environment is challenging as environmental factors may also impact the outcome of these interactions. A more integrative research approach is needed to clarify how mosquito-associated microbiota can mediate ecologically important traits and thereby contribute to mosquito biology.

For this Special Issue of the journal Pathogens, we would like to invite submissions of research papers, review articles, or short communications presenting recent advances related to our knowledge of mosquito–microbiota interactions in terms of microbiota and evolution, manipulation of microbiota, microbiota functions, environmental impacts on mosquito–microbiota, molecular mechanisms of interactions, and strategies for mosquito control. I look forward to your contributions!

Assoc. Prof. Claire Valiente-Moro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mosquito control
  • microbiota diversity and functions
  • mosquito–microbiota co-evolution
  • pathogen interference
  • influence of environment
  • microbial network interactions

Published Papers (1 paper)

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Research

Open AccessArticle
Inhibition of Asaia in Adult Mosquitoes Causes Male-Specific Mortality and Diverse Transcriptome Changes
Pathogens 2020, 9(5), 380; https://doi.org/10.3390/pathogens9050380 - 15 May 2020
Abstract
Mosquitoes can transmit many infectious diseases, such as malaria, dengue, Zika, yellow fever, and lymphatic filariasis. Current mosquito control strategies are failing to reduce the severity of outbreaks that still cause high human morbidity and mortality worldwide. Great expectations have been placed on [...] Read more.
Mosquitoes can transmit many infectious diseases, such as malaria, dengue, Zika, yellow fever, and lymphatic filariasis. Current mosquito control strategies are failing to reduce the severity of outbreaks that still cause high human morbidity and mortality worldwide. Great expectations have been placed on genetic control methods. Among other methods, genetic modification of the bacteria colonizing different mosquito species and expressing anti-pathogen molecules may represent an innovative tool to combat mosquito-borne diseases. Nevertheless, this emerging approach, known as paratransgenesis, requires a detailed understanding of the mosquito microbiota and an accurate characterization of selected bacteria candidates. The acetic acid bacteria Asaia is a promising candidate for paratransgenic approaches. We have previously reported that Asaia symbionts play a beneficial role in the normal development of Anopheles mosquito larvae, but no study has yet investigated the role(s) of Asaia in adult mosquito biology. Here we report evidence on how treatment with a highly specific anti-Asaia monoclonal antibody impacts the survival and physiology of adult Anopheles stephensi mosquitoes. Our findings offer useful insight on the role of Asaia in several physiological systems of adult mosquitoes, where the influence differs between males and females. Full article
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