New Advances in Antiparasitic Drug Development: Targets, Strategies, and Challenges

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 775

Special Issue Editor


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Laboratório de Farmacologia e Bioquímica (LFBq), Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Pirassununga 13635-900, SP, Brazil
Interests: pathogen biochemistry and pharmacology; neglected disease (leishmaniasis); drug development
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Special Issue Information

Dear Colleagues,

This Special Issue focuses on the latest breakthroughs in antiparasitic drug development, exploring promising new targets, innovative strategies, and persistent challenges in combating parasitic diseases. It delves into the identification and validation of novel drug targets within parasites, encompassing crucial proteins, enzymes, and pathways essential for their survival and pathogenesis. Cutting-edge strategies, such as rational drug design, high-throughput screening, and drug repurposing, are examined in detail.

The Special Issue also addresses the significant challenges faced in antiparasitic drug development, including drug resistance, host toxicity, and the need for improved delivery systems. It highlights the importance of interdisciplinary collaborations and global partnerships to accelerate the discovery and development of effective antiparasitic therapies. This Special Issue centers upon the most recent advancements in antiparasitic drug development, investigating prospective novel targets, pioneering strategies, and enduring challenges in the fight against parasitic diseases.

Dr. Edson Roberto da Silva
Guest Editor

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Keywords

  • malaria
  • leishmania
  • trypanossoma
  • helminths
  • antiparasitc drugs

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Published Papers (1 paper)

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Research

8 pages, 703 KiB  
Communication
Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of Leishmania amazonensis Promastigotes and Intracellular Amastigotes
by Edson Roberto da Silva, André Mesquita and Claudia do Carmo Maquiaveli
Pathogens 2025, 14(4), 384; https://doi.org/10.3390/pathogens14040384 - 15 Apr 2025
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Abstract
Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against Leishmania amazonensis. CAPE exhibited IC50 values of 8.07 µM (95% [...] Read more.
Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against Leishmania amazonensis. CAPE exhibited IC50 values of 8.07 µM (95% CI, 6.79–9.62 µM) and 13.51 µM (95% CI, 10.71–17.16 µM) against L. amazonensis promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited L. amazonensis arginase in a non-competitive manner with a Ki value of 1.51 ± 0.04 µM. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis. Full article
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